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2019冠状病毒病与牙周炎严重程度的相关性——一项临床与生化研究

Correlation of COVID-19 with severity of periodontitis-A clinical and biochemical study.

作者信息

Kalsi Rupali, Ahmad Zoya, Siddharth Mallapragada, Vandana Kharidhi Laxman, Arora Sachit Anand, Saurav Kumar

机构信息

Department of Dentistry, Government Institute of Medical Sciences, Gautham Buddha Nagar, Uttar Pradesh, India.

Department of Periodontics, ITS Dental College, Greater Noida, Uttar Pradesh, India.

出版信息

Indian J Dent Res. 2022 Jul-Sep;33(3):307-312. doi: 10.4103/ijdr.ijdr_1168_21.

DOI:10.4103/ijdr.ijdr_1168_21
PMID:36656194
Abstract

BACKGROUND

Various conceptual hypotheses have been put forth to link association of COVID-19 with various chronic diseases such as periodontitis. Empirical evidence is still lacking to correlate the severity of COVID-19 with periodontal diseases.

OBJECTIVES

This study was undertaken with an objective to correlate COVID severity in systemically healthy patients suffering from periodontal diseases.

MATERIALS AND METHODS

44 systemically healthy patients of both genders with minimum of 20 teeth in their oral cavity in age range of 20 to 50 years suffering from periodontitis were recruited and categorised into four stages as per American Academy of Periodontology (AAP) 2017 classification for periodontitis. Serum C-reactive protein (CRP) levels and periodontal disease parameters of all the patients were measured. Because of COVID-19 and the nationwide lockdown, the dental practice was highly affected. With the help of self-designed online questionnaire information regarding COVID-19 infection and associated symptoms were recorded. Cases were categorized into five groups based on the World Health Organization clinical progression scale of COVID severity.

RESULTS

All the patients suffering from COVID disease in moderate and severe forms had increased probing pocket depth, clinical attachment level, and raised serum C-reactive protein levels as compared to patients who were uninfected or suffering from mild COVID disease and the results were statistically significant.

CONCLUSION

Prioritisation and Implementation of periodontal treatment as a preventive measure for COVID-19 should be done. A positive correlation is observed between the severity of periodontitis and COVID-19.

摘要

背景

已经提出了各种概念性假设,以将新冠病毒疾病(COVID-19)与诸如牙周炎等各种慢性疾病的关联联系起来。目前仍缺乏将COVID-19的严重程度与牙周疾病相关联的实证证据。

目的

本研究旨在关联患有牙周疾病的全身健康患者的COVID严重程度。

材料和方法

招募了44名年龄在20至50岁之间、口腔中至少有20颗牙齿且患有牙周炎的全身健康的男女患者,并根据美国牙周病学会(AAP)2017年牙周炎分类将其分为四个阶段。测量了所有患者的血清C反应蛋白(CRP)水平和牙周疾病参数。由于COVID-19和全国范围的封锁,牙科诊疗受到了极大影响。借助自行设计的在线问卷,记录了有关COVID-19感染及相关症状的信息。根据世界卫生组织的COVID严重程度临床进展量表,将病例分为五组。

结果

与未感染或患有轻度COVID疾病的患者相比,所有患有中度和重度COVID疾病的患者的探诊深度增加、临床附着水平增加,血清C反应蛋白水平升高,且结果具有统计学意义。

结论

应将牙周治疗作为COVID-19的预防措施进行优先排序和实施。观察到牙周炎严重程度与COVID-19之间存在正相关。

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The impact of periodontal disease on the clinical outcomes of COVID-19: A systematic review and meta-analysis.牙周病对 COVID-19 临床结局的影响:系统评价和荟萃分析。
BMC Oral Health. 2023 Sep 9;23(1):658. doi: 10.1186/s12903-023-03378-0.