Department of Pharmacy, Chengdu Military General Hospital, Chengdu, Sichuan 610083, P.R. China.
Institute of Organ Transplantation, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China.
Mol Med Rep. 2018 Dec;18(6):4775-4786. doi: 10.3892/mmr.2018.9529. Epub 2018 Oct 2.
Mangiferin (1,3,6,7‑tetrahydroxyxanthone‑C2‑β‑D‑glucoside) is a bioactive ingredient predominantly isolated from the mango tree, with potent antioxidant activity and multifactorial pharmacological effects, including antidiabetic, antitumor, lipometabolism regulating, cardioprotective, anti‑hyperuricemic, neuroprotective, antioxidant, anti‑inflammatory, antipyretic, analgesic, antibacterial, antiviral and immunomodulatory effects. Therefore, it possesses several health‑endorsing properties and is a promising candidate for further research and development. However, low solubility, mucosal permeability and bioavailability restrict the development of mangiferin as a clinical therapeutic, and chemical and physical modification is required to expand its application. This review comprehensively analyzed and collectively summarized the primary pharmacological actions of mangiferin that have been demonstrated in the literature, to support the potential future development of mangiferin as a novel therapeutic drug.
芒果苷（1,3,6,7-四羟基呫吨酮-C2-β-D-葡萄糖苷）是一种主要从芒果树中分离得到的生物活性成分，具有强大的抗氧化活性和多方面的药理作用，包括抗糖尿病、抗肿瘤、调节脂代谢、心脏保护、抗高尿酸血症、神经保护、抗氧化、抗炎、解热、镇痛、抗菌、抗病毒和免疫调节作用。因此，它具有多种健康促进特性，是进一步研究和开发的有前途的候选药物。然而，低溶解度、黏膜通透性和生物利用度限制了芒果苷作为临床治疗药物的发展，需要进行化学和物理修饰以扩大其应用。本综述全面分析和综合总结了文献中已经证明的芒果苷的主要药理作用，以支持将芒果苷作为新型治疗药物的潜在未来发展。
