Dogra Nitu, Jakhmola-Mani Ruchi, Potshangbam Angamba Meetei, Buch Shilpa, Pande Katare Deepshikha
Proteomics and Translational Research Lab, Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, India, 201301.
Department of Biotechnology, Manipur University, Canchipur, Imphal, Manipur, India, 795003.
Metab Brain Dis. 2023 Mar;38(3):1079-1096. doi: 10.1007/s11011-022-01155-6. Epub 2023 Jan 19.
Parkinson's disease (PD) is a chronic, progressive, and second most prevalent neurological disorder affecting the motor system. It has been found that people suffering with inflammatory bowel disease (IBD) are at 22% more risk for PD. In the current study, we have established a molecular link between gut and brain. The microarray gene expression datasets of Homo sapiens were obtained from Gene Expression Omnibus Database. Major genes involved in gut-brain connection were found to be CXCR4, LRRK2, APOE, SNCA, IL6, HIF-1α, ABCA1 etc. The common biological pathways linking both the pathologies were found to be HIF-signaling, cytokines interactions, JAK-STAT pathway, cholesterol metabolism, apoptosis and CXCR4 signaling which modulates the synaptic function and neuronal survival in the mature brain. It is known that flavonoid-rich foods throughout life hold the potential to limit the inflammation, neurodegeneration and, to prevent the age-dependent cognitive impairment. Therefore, the potential receptor, CXCR4 was used further for docking with twenty-seven phytochemicals from 5 different classes of Flavonoids found in several dietary items. Docking studies of the top scoring compounds were compared with a known inhibitor (BPRCX807) of receptor CXCR4 (IC = 40.4 ± 8.0 nM). The study indicates that Flavan-3-ol families of flavonoids are the best fit and finest dietary supplements for improving brain health. Hence the food items like Pistachio nuts, hazelnuts, Green Tea, walnuts, etc. should be incorporated more in the diet of healthy people as well as in IBD and PD patients to prevent inflammation in gut and brain damage from oxidative stress.
帕金森病（PD）是一种影响运动系统的慢性、进行性且第二常见的神经系统疾病。研究发现，患有炎症性肠病（IBD）的人患帕金森病的风险要高22%。在当前的研究中，我们已经建立了肠道与大脑之间的分子联系。人类的微阵列基因表达数据集是从基因表达综合数据库中获取的。发现参与肠道与大脑联系的主要基因有CXCR4、LRRK2、APOE、SNCA、IL6、HIF-1α、ABCA1等。发现连接这两种病症的常见生物学途径有HIF信号传导、细胞因子相互作用、JAK-STAT途径、胆固醇代谢、细胞凋亡和CXCR4信号传导，这些途径调节成熟大脑中的突触功能和神经元存活。众所周知，终生食用富含类黄酮的食物有可能限制炎症、神经退行性变，并预防与年龄相关的认知障碍。因此，进一步使用潜在受体CXCR4与在几种食物中发现的5种不同类别的黄酮类化合物中的27种植物化学物质进行对接。将得分最高的化合物的对接研究与受体CXCR4的已知抑制剂（BPRCX807，IC = 40.4±8.0 nM）进行比较。该研究表明，黄酮类化合物中的黄烷-3-醇家族是改善大脑健康的最佳选择和优质膳食补充剂。因此，开心果、榛子、绿茶、核桃等食物应该更多地纳入健康人群以及IBD和PD患者的饮食中，以预防肠道炎症和氧化应激对大脑的损害。
