Research and Teaching Department of Comparative Medicine, Dalian Medical University, Dalian, 116044, China.
Central Laboratory, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Inflamm Res. 2021 Jul;70(7):753-764. doi: 10.1007/s00011-021-01482-x. Epub 2021 Jul 1.
Janus kinase/signal transduction and transcriptional activator (JAK/STAT) signaling pathway is a transport hub for cytokine secretion and exerts its effects. The activation of JAK/STAT signaling pathway is essential for the regulation of inflammatory responses. Inappropriate activation or deletion of JAK/STAT signaling pathway is the initiator of the inflammatory response. JAK/STAT signaling pathway has been demonstrated to be involved in the process of innate and adaptive immune response to inflammatory bowel disease (IBD). In this review, we discuss the role of the JAK/STAT signaling pathway in the regulation of different cells in IBD, as well as new findings on the involvement of the JAK/STAT signaling pathway in the regulation of the intestinal immune response. The current status of JAK inhibitors in the treatment of IBD is summarized as well. This review highlights natural remedies that can serve as potential JAK inhibitors. These phytochemicals may be useful in the identification of precursor compounds in the process of designing and developing novel JAK inhibitors.
Janus 激酶/信号转导和转录激活因子（JAK/STAT）信号通路是细胞因子分泌的运输枢纽，并发挥其作用。JAK/STAT 信号通路的激活对于调节炎症反应至关重要。JAK/STAT 信号通路的异常激活或缺失是炎症反应的启动因素。JAK/STAT 信号通路已被证明参与了对炎症性肠病（IBD）的先天和适应性免疫反应的调节。在这篇综述中，我们讨论了 JAK/STAT 信号通路在 IBD 中调节不同细胞的作用，以及 JAK/STAT 信号通路在调节肠道免疫反应中的新发现。还总结了 JAK 抑制剂在治疗 IBD 中的现状。本文综述强调了天然药物作为潜在 JAK 抑制剂的作用。这些植物化学物质可能有助于在设计和开发新型 JAK 抑制剂的过程中确定前体化合物。
