Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
GI Diseases Research Unit, Queens University, Kingston, Ontario, Canada.
Gut Microbes. 2023 Jan-Dec;15(1):2166780. doi: 10.1080/19490976.2023.2166780.
Visceral hypersensitivity, a fundamental mechanism of chronic visceral pain disorders, can result from both central or peripheral factors, or their combination. As an important regulator of normal gut function, the gut microbiota has been implicated as a key peripheral factor in the pathophysiology of visceral hypersensitivity. Patients with chronic gastrointestinal disorders, such as irritable bowel syndrome, often present with abdominal pain secondary to adverse reactions to dietary components. As both long- and short-term diets are major determinants of gut microbiota configuration that can result in changes in microbial metabolic output, it is becoming increasingly recognized that diet-microbiota interactions play an important role in the genesis of visceral sensitivity. Changes in pain signaling may occur via diet-induced changes in secretion of mediators by both the microbiota and/or host cells. This review will examine the peripheral influence of diet-microbiota interactions underlying increased visceral sensitivity.
内脏敏感性是慢性内脏疼痛障碍的一个基本机制，它可能源于中枢或外周因素，或两者的组合。作为正常肠道功能的重要调节者，肠道微生物群已被认为是内脏敏感性病理生理学中的一个关键外周因素。患有慢性胃肠道疾病（如肠易激综合征）的患者常因对饮食成分的不良反应而出现腹痛。由于长期和短期饮食都是肠道微生物群结构的主要决定因素，这种结构的改变会导致微生物代谢产物的变化，因此越来越多的人认识到饮食-微生物群相互作用在内脏敏感性的产生中起着重要作用。疼痛信号的变化可能是通过饮食诱导的微生物群和/或宿主细胞分泌介质的变化而发生的。这篇综述将探讨饮食-微生物群相互作用对内脏敏感性增加的外周影响。
