Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
PLoS One. 2023 Jan 19;18(1):e0279087. doi: 10.1371/journal.pone.0279087. eCollection 2023.
Erectile dysfunction (ED) has been reported among patients with systemic sclerosis (SSc) and primarily limited cutaneous SSc in Caucasians. While there is no data on ED among Thais in whom the diffuse cutaneous SSc subset is common.
We aimed to estimate the prevalence of ED among Thais with SSc, evaluate its severity, and determine the associated factors.
We did a cross-sectional study among adult Thai male SSc patients. All eligible patients: a) completed the IIEF-15 questionnaire by themselves; b) underwent a genital examination by an experienced urologist to evaluate skin tightness of the penis, scrotum, and phimosis; and, c) were evaluated for Erection Hardness Score.
A total of 60 male SSc patients were included. The respective mean age and median disease duration was 54.8±7.2 years and 3.1 years (IQR 1.2-7.2). The definition of ED was fulfilled in 53 cases for a prevalence of 88.3% (95%CI 77.4-95.2), while 65% had severe ED, and none had skin tightness of the genitalia. Eight cases had acquired phimosis, and all were in the ED group. The patients with ED vs. those without ED had significantly lower scores for orgasm, sexual desire, and intercourse satisfaction, and trended to be older, have more severe skin tightness and have higher BMI.
ED is a common problem in men with SSc and is mainly categorized as severe. The severity of SSc might increase the risk of developing ED. We found phimosis was a common genital abnormality co-occurring with ED in SSc.
勃起功能障碍（ED）在系统性硬化症（SSc）患者中，尤其是在白种人中的局限性皮肤 SSc 患者中已有报道。而在弥漫性皮肤 SSc 亚型常见的泰国人中，尚无关于 ED 的数据。
我们旨在估计泰国 SSc 男性患者中 ED 的患病率，评估其严重程度，并确定相关因素。
我们在成年泰国男性 SSc 患者中进行了一项横断面研究。所有符合条件的患者：a）自行完成 IIEF-15 问卷；b）由经验丰富的泌尿科医生进行生殖器检查，以评估阴茎、阴囊和包茎的皮肤紧绷程度；c）评估勃起硬度评分。
共纳入 60 例男性 SSc 患者。患者的平均年龄和中位疾病持续时间分别为 54.8±7.2 岁和 3.1 年（IQR 1.2-7.2）。53 例患者符合 ED 定义，患病率为 88.3%（95%CI 77.4-95.2），65%的患者存在严重 ED，且无患者存在生殖器皮肤紧绷。8 例患者存在获得性包茎，且均在 ED 组。ED 患者与无 ED 患者相比，性高潮、性欲和性交满意度评分显著降低，且年龄较大，皮肤紧绷程度更严重，BMI 更高。
ED 是 SSc 男性患者的常见问题，主要为严重类型。SSc 的严重程度可能会增加发生 ED 的风险。我们发现包茎是 SSc 患者中常见的生殖器异常，与 ED 同时发生。
