Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen, 40002, Thailand.
Clin Rheumatol. 2023 Jul;42(7):1767-1774. doi: 10.1007/s10067-023-06550-7. Epub 2023 Mar 10.
A better understanding of the epidemiological profile of systemic sclerosis (SSc) in Thais could improve care, human resource deployment, and public health budgeting.
We aimed to determine the incidence and prevalence of SSc in Thailand between 2017 and 2020.
A descriptive epidemiological study was performed using the Information and Communication Technology Center, Ministry of Public Health database, comprising all types of healthcare providers during the study period. Demographic data of patients having a primary diagnosis of M34 systemic sclerosis and over 18 years of age between 2017 and 2020 were reviewed. The incidence and prevalence of SSc were calculated as well as their respective 95% confidence intervals (CIs).
The number of SSc cases in 2017 was 15,920 from a total Thai population of 65,204,797. The prevalence of SSc in 2017 was 24.4 per 100,000 populations (95% CI 24.0-24.8). The prevalence of SSc among women was 2 times greater than among men (32.7 vs. 15.8 per 100,000). The incidence of SSc was stable from 2018 to 2019 but dropped slightly in 2020 (7.2, 7.6, and 6.8 per 100,000 person-years, respectively). Most SSc cases were in northeastern Thailand (11.6, 12.1, and 11.1 per 100,000 person-years from 2018 to 2020, respectively) and the peak was between 60 and 69 years of age (24.6, 23.8, and 20.9 per 100,000 person-years from 2018 to 2020, respectively).
SSc is a rare disease among Thais. The disease was commonly revealed in late middle-aged women with a peak at age 60-69 years, mainly from the northeast regions. The incidence remained stable during the study period, albeit during the emergence of the coronavirus pandemic a slight decline was recorded. Key Points • The incidence and prevalence of systemic sclerosis (SSc) vary across ethnic populations. • There is a lack of epidemiology research of SSc since the 2013 ACR/EULAR Classification Criteria for Scleroderma was adopted among Thais included Asia-Pacific population as the population has some different clinical features than those reported among Caucasians. • SSc is a rare connective disease among Thais and commonly presents in late middle-aged group of both genders, mainly in Thailand's northern and northeastern regions. • When compare to the epidemiology of SSc in Asia-Pacific, the prevalence of SSc in Thais was higher than among East Asians and the Indian population and the incidence of SSc among Thais was greater than the other Asia-Pacific population including Australian.
深入了解泰国系统性硬化症（SSc）的流行病学特征，有助于改善医疗服务、人力资源部署和公共卫生预算。
本研究旨在确定 2017 年至 2020 年期间泰国 SSc 的发病率和患病率。
本研究采用描述性流行病学研究方法，利用泰国公共卫生部信息和通信技术中心数据库，对研究期间所有类型的医疗保健提供者进行分析。回顾了年龄在 18 岁及以上、初次诊断为 M34 系统性硬化症的患者的人口统计学数据。计算了 SSc 的发病率和患病率，并计算了各自的 95%置信区间（CI）。
2017 年，泰国总人口为 65204797 人，SSc 病例为 15920 例，发病率为 24.4/100000 人（95%CI 24.0-24.8）。女性 SSc 的患病率是男性的 2 倍（32.7/100000 人比 15.8/100000 人）。2018 年至 2019 年，SSc 的发病率保持稳定，但 2020 年略有下降（分别为 7.2、7.6 和 6.8/100000 人年）。大多数 SSc 病例发生在泰国东北部（2018 年至 2020 年分别为 11.6、12.1 和 11.1/100000 人年），发病高峰在 60-69 岁（2018 年至 2020 年分别为 24.6、23.8 和 20.9/100000 人年）。
SSc 在泰国是一种罕见疾病。这种疾病通常在中年后期女性中发现，发病高峰在 60-69 岁，主要来自东北部地区。在研究期间，发病率保持稳定，尽管在冠状病毒大流行期间略有下降。
系统性硬化症（SSc）的发病率和患病率在不同种族人群中有所不同。
自从泰国纳入亚太地区人群后，采用了 2013 年 ACR/EULAR 系统性硬化症分类标准，因此，泰国 SSc 的流行病学研究较少，该人群的临床特征与白种人报道的有所不同。
SSc 在泰国是一种罕见的结缔组织疾病，主要发生在中晚期的两性人群中，主要在泰国北部和东北部地区。
与亚太地区 SSc 的流行病学相比，泰国 SSc 的患病率高于东亚和印度人群，泰国 SSc 的发病率高于包括澳大利亚在内的其他亚太人群。
