Faculty of Medicine, Universidad Autónoma de Coahuila, Coahuila, Mexico.
Faculty of Medicine, Universidad de la República, Montevideo, Uruguay.
Gac Med Mex. 2022;158(6):410-415. doi: 10.24875/GMM.M22000720.
Genetic variants related to bone morphogenetic proteins (BMP2, BMP4, GREM1, SMAD7) signaling pathway have been associated with colorectal cancer, mainly in Caucasian populations.
To describe the association of variants in members of the BMP signaling pathway in a Mexican population, characterized by its indigenous American and Caucasian ancestry.
Genotyping of 1,000 colorectal cancer cases and 1,043 control individuals recruited in Mexico City, Monterrey, and Torreón was carried out using the Sequenom platform. Associations between colorectal cancer and variants were studied with univariate and multivariate analyses.
Variants rs4444235, rs12953717 and rs4939827 replicated the association with the neoplasm (p ≤ 0.05). Caucasian ancestry showed association with the tumor.
The study replicated the associations between colorectal cancer and SMAD7 and BMP4 variants, with an association being observed with the Caucasian component of the ethnic mix.
与骨形态发生蛋白（BMP2、BMP4、GREM1、SMAD7）信号通路相关的遗传变异与结直肠癌有关，主要在白种人群中。
描述 BMP 信号通路成员在具有美洲原住民和白种人血统的墨西哥人群中的关联。
使用 Sequenom 平台对来自墨西哥城、蒙特雷和托雷翁的 1000 例结直肠癌病例和 1043 例对照个体进行基因分型。使用单变量和多变量分析研究了结直肠癌与变异之间的关系。
rs4444235、rs12953717 和 rs4939827 变异与肿瘤（p≤0.05）的相关性得到了复制。白种人血统与肿瘤有关。
该研究复制了结直肠癌与 SMAD7 和 BMP4 变异之间的关联，并观察到与种族混合的白种人成分有关。
