Zhang Xueling, Li Congcong, Wu Yue, Cui Peilin
Department of Internal Medicine, International Medical Services (IMS), Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Department of Internal Medicine, International Medical Services (IMS), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Clin Res Hepatol Gastroenterol. 2023 Mar;47(3):102086. doi: 10.1016/j.clinre.2023.102086. Epub 2023 Jan 16.
The Wnt/β-catenin signaling pathway is highly conservative. β-catenin is the key molecule in this pathway. The β-catenin target genes regulate cell proliferation and apoptosis. Since Wnt pathway proteins are distributed on the cell membrane, cytoplasm, and nucleus, inhibiting or activating these pathway proteins presents a novel target for cancer treatment via the Wnt signaling pathway. Studies have found that this pathway plays a significant role in the formation and progression of cancers, particularly colorectal cancer. We summarised the activation and inhibition of the Wnt signaling pathway in tumors, its relationship with the microenvironment and crosstalk with other pathways, and the effect of targeting abnormal Wnt signaling in the treatment of colorectal cancer. Here is to review future targeted therapeutics in colorectal cancer research and implementation.
Wnt/β-连环蛋白信号通路高度保守。β-连环蛋白是该信号通路中的关键分子。β-连环蛋白靶基因调节细胞增殖和凋亡。由于Wnt信号通路蛋白分布于细胞膜、细胞质和细胞核，抑制或激活这些信号通路蛋白为通过Wnt信号通路治疗癌症提供了新靶点。研究发现，该信号通路在癌症尤其是结直肠癌的形成和进展中起重要作用。我们总结了肿瘤中Wnt信号通路的激活与抑制、其与微环境的关系以及与其他信号通路的相互作用，以及靶向异常Wnt信号在结直肠癌治疗中的作用。本文旨在综述结直肠癌研究与治疗中未来的靶向疗法。
