School of Chemical Engineering, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, South Korea.
Division of Gastroenterology & Hepatology, School of Medicine, Institute for Regenerative Cures, University of California Davis, 2921 Stockton Boulevard, Sacramento, CA 95817, USA.
Int J Biol Macromol. 2023 Mar 31;232:123283. doi: 10.1016/j.ijbiomac.2023.123283. Epub 2023 Jan 17.
Hydrogels have emerged as a versatile platform for a numerous biomedical application due to their ability to absorb a huge quantity of biofluids. In order to design hydrogels, natural polymers are an attractive option owing to their biocompatibility and biodegradability. Due to abundance in occurrence, cost effectiveness, and facile crosslinking approaches, alginate has been extensively investigated to fabricate hydrogel matrix. Management of cancer and chronic wounds have always been a challenge for pharmaceutical and healthcare sector. In both cases, curcumin have been shown significant improvement and effectiveness. However, the innate restraints like poor bioavailability, hydrophobicity, and rapid systemic clearance associated with curcumin have restricted its clinical translations. The current review explores the cascade of research around curcumin encapsulated alginate hydrogel matrix for wound healing and cancer therapy. The focus of the review is to emphasize the mechanistic effects of curcumin with its fate inside the cells. Further, the review discusses different approaches to designed curcumin loaded alginate hydrogels along with the parameters that regulates their release behavior. Finally, the review is concluded with emphasize on some key aspect on increasing the efficacy of these hydrogels along with novel strategies to further develop curcumin loaded alginate hydrogel matrix with multifacet applications.
水凝胶因其能够吸收大量生物流体而成为许多生物医学应用的多功能平台。为了设计水凝胶，天然聚合物是一种有吸引力的选择，因为它们具有生物相容性和可生物降解性。由于丰富的存在、成本效益和简单的交联方法，海藻酸盐已被广泛研究用于制造水凝胶基质。癌症和慢性伤口的管理一直是制药和医疗保健行业的一个挑战。在这两种情况下，姜黄素都显示出了显著的改善和效果。然而，姜黄素与较差的生物利用度、疏水性和快速的全身清除率等内在限制，限制了其临床应用。本综述探讨了姜黄素包封的海藻酸盐水凝胶基质在伤口愈合和癌症治疗方面的一系列研究。综述的重点是强调姜黄素在细胞内的作用机制。此外，本综述还讨论了设计姜黄素负载的海藻酸盐水凝胶的不同方法以及调节其释放行为的参数。最后，本文强调了提高这些水凝胶疗效的一些关键方面，并提出了一些新的策略，以进一步开发具有多方面应用的姜黄素负载的海藻酸盐水凝胶基质。
