Yan Suyan, Li Meiqi, Liu Baocheng, Ma Zhenzhen, Yang Qingrui
Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jingwu Road, Huaiyin District, Jinan, 250021, Shandong, China.
J Inflamm (Lond). 2023 Jan 19;20(1):2. doi: 10.1186/s12950-023-00329-y.
Pulmonary fibrosis (PF) is a serious and often fatal illness that occurs in various clinical settings and represents a significant unmet medical need. Increasing evidence indicates that neutrophil extracellular traps (NETs) contribute significantly to the progression of PF. Therefore, understanding the pathways by which NETs contribute to the disease is crucial for developing effective treatments. This review focuses on the formation of NETs and the common mechanisms of NETs in PF.
肺纤维化（PF）是一种严重且往往致命的疾病，发生于多种临床情况，代表着重大的未满足医疗需求。越来越多的证据表明，中性粒细胞胞外陷阱（NETs）在PF的进展中起重要作用。因此，了解NETs促成该疾病的途径对于开发有效治疗方法至关重要。本综述聚焦于NETs的形成以及NETs在PF中的常见机制。
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