Gallino A, Jenni R, Hurni R, Hirzel H O, Krayenbühl H P, Egloff L, Rothlin M, Schönbeck M, Turina M
Department of Medicine, University Hospital, Zürich, Switzerland.
Eur Heart J. 1987 Aug;8(8):902-5. doi: 10.1093/oxfordjournals.eurheartj.a062355.
In this study we present the results of 105 consecutive patients with pure mitral regurgitation who underwent surgical treatment. In all patients mitral regurgitation was associated with mitral valve prolapse: 54 patients underwent mitral valvuloplasty and 51 patients mitral valve replacement. Clinical assessment and echocardiography were used as follow-up criteria at one year after surgery. After mitral valvuloplasty, NYHA decreased from 2.7 +/- 0.8 to 1.1 +/- 0.7 (P less than 0.01) and workload capacity increased from 65 +/- 28% to 96 +/- 25% (P less than 0.001); left endsystolic atrial dimension and enddiastolic dimension decreased from 6.2 +/- 0.8 to 4.8 +/- 1.2 cm (P less than 0.001) and from 7.2 +/- 1.3 to 5.9 +/- 0.8 cm (P less than 0.01); ventricular contraction fraction did not change significantly. After mitral valve replacement, clinical and echocardiographic improvement was significant but less remarkable than after valvuloplasty; ventricular contraction fraction fell from 39 +/- 7% to 29 +/- 8% in contrast to patients undergoing mitral valvuloplasty in whom no significant change occurred. Complications were rare in both groups though only a minority of patients undergoing mitral valvuloplasty received anticoagulants. We conclude that mitral valvuloplasty in patients with pure mitral regurgitation when compared with the patients after mitral valve replacement.
在本研究中,我们呈现了105例接受手术治疗的单纯二尖瓣反流患者的结果。所有患者的二尖瓣反流均与二尖瓣脱垂相关:54例患者接受了二尖瓣成形术,51例患者接受了二尖瓣置换术。术后一年,采用临床评估和超声心动图作为随访标准。二尖瓣成形术后,纽约心脏协会(NYHA)分级从2.7±0.8降至1.1±0.7(P<0.01),工作量能力从65±28%增至96±25%(P<0.001);左心房收缩末期内径和舒张末期内径分别从6.2±0.8降至4.8±1.2 cm(P<0.001)和从7.2±1.3降至5.9±0.8 cm(P<0.01);心室收缩分数无显著变化。二尖瓣置换术后,临床和超声心动图改善显著,但不如二尖瓣成形术后明显;与二尖瓣成形术患者心室收缩分数无显著变化相反,二尖瓣置换术患者的心室收缩分数从39±7%降至29±8%。两组并发症均少见,尽管只有少数接受二尖瓣成形术的患者接受了抗凝治疗。我们得出结论,与二尖瓣置换术后患者相比,单纯二尖瓣反流患者行二尖瓣成形术……(原文最后似乎不完整)