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外阴滑膜肉瘤:一例报告及文献复习并讨论保留生育功能的方法

Synovial sarcoma of the vulva: A case report and literature review with discussion on fertility sparing approaches.

作者信息

Schoettle Gabriella, Gulstene Stephanie, Vickress Jason, Sugimoto Akira, D'Souza David

机构信息

Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

Division of Radiation Oncology, Department of Oncology, London Health Sciences Centre, London, Ontario, Canada.

出版信息

Gynecol Oncol Rep. 2023 Jan 8;45:101132. doi: 10.1016/j.gore.2023.101132. eCollection 2023 Feb.

DOI:10.1016/j.gore.2023.101132
PMID:36659908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9842853/
Abstract

•Vulvar synovial sarcoma is a rare malignancy with unclear treatment guidelines but usually includes surgical resection.•Our literature review demonstrates additional survival benefit from addition of radiotherapy to surgical resection.•There is no specific guidance in the literature for the addition of systemic agents to treat vulvovaginal disease.•Our patient received wide surgical excision and IMRT radiotherapy with no signs of recurrence 2 years from treatment.•She conceived after treatment. This has only been documented once before with different, less accessible treatments.

摘要

•外阴滑膜肉瘤是一种罕见的恶性肿瘤,治疗指南尚不明确,但通常包括手术切除。

•我们的文献综述表明,手术切除加放疗可带来额外的生存获益。

•文献中没有关于添加全身治疗药物来治疗外阴阴道疾病的具体指导。

•我们的患者接受了广泛手术切除和调强适形放疗,治疗后2年无复发迹象。

•她在治疗后怀孕了。此前仅有一次关于不同且较难获得的治疗方法后怀孕的记录。

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本文引用的文献

1
Synovial Sarcoma: A Clinical Review.滑膜肉瘤:临床综述。
Curr Oncol. 2021 May 19;28(3):1909-1920. doi: 10.3390/curroncol28030177.
2
Synovial Sarcoma of the Female Genital Tract: A Protean Mimic of Müllerian Neoplasia.女性生殖道滑膜肉瘤:黏液性肿瘤的多形性模拟。
Am J Surg Pathol. 2020 Nov;44(11):1487-1495. doi: 10.1097/PAS.0000000000001538.
3
The Imaging Spectrum of Synovial Sarcomas: A Pictorial Review From a Single-Centre Tertiary Referral Institution.滑膜肉瘤的影像学表现:单中心三级转诊机构的图像回顾。
Can Assoc Radiol J. 2021 Aug;72(3):470-482. doi: 10.1177/0846537119899284. Epub 2020 Feb 18.
4
An Introduction to the Intensity-modulated Radiation Therapy (IMRT) Techniques, Tomotherapy, and VMAT.调强放射治疗(IMRT)技术、断层放射治疗和容积调强弧形治疗的介绍。
J Med Imaging Radiat Sci. 2011 Mar;42(1):37-43. doi: 10.1016/j.jmir.2010.11.005.
5
Modern radiation therapy and potential fertility preservation strategies in patients with cervical cancer undergoing chemoradiation.接受放化疗的宫颈癌患者的现代放射治疗及潜在生育力保护策略
Radiat Oncol. 2015 Feb 22;10:50. doi: 10.1186/s13014-015-0353-4.
6
Effects of Adjuvant Radiotherapy in Patients With Synovial Sarcoma.辅助放疗对滑膜肉瘤患者的影响。
Am J Clin Oncol. 2017 Jun;40(3):306-311. doi: 10.1097/COC.0000000000000148.
7
Synovial sarcoma of the vulva: a case report.外阴滑膜肉瘤:一例报告
J Med Case Rep. 2011 Mar 10;5:95. doi: 10.1186/1752-1947-5-95.
8
Synovial sarcoma of the vulva and vagina: a clinicopathologic and molecular genetic study of 4 cases.外阴和阴道滑膜肉瘤:4 例临床病理和分子遗传学研究。
Int J Gynecol Pathol. 2011 Jan;30(1):84-91. doi: 10.1097/PGP.0b013e3181f0c510.
9
A multidisciplinary approach to fertility-sparing therapy for a rare vulvar tumor.一种针对罕见外阴肿瘤的保留生育功能治疗的多学科方法。
Fertil Steril. 2010 Jan;93(1):267.e5-7. doi: 10.1016/j.fertnstert.2009.07.1007. Epub 2009 Dec 3.
10
Fertility and pregnancy outcome after abdominal irradiation that included or excluded the pelvis in childhood tumor survivors.儿童肿瘤幸存者腹部放疗时骨盆照射与否对生育和妊娠结局的影响。
Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3):867-73. doi: 10.1016/j.ijrobp.2009.04.012. Epub 2009 Jul 23.