Ghadjar Pirus, Budach Volker, Köhler Christhardt, Jantke Andreas, Marnitz Simone
Department of Radiation Oncology, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Department of Gynecology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Radiat Oncol. 2015 Feb 22;10:50. doi: 10.1186/s13014-015-0353-4.
Young patients with cervical cancer who undergo chemoradiation might be interested in fertility preservation, not only dependent upon the use of a gestational carrier as maybe achieved by the use of ovarian transposition and cryo-conservation of oocytes or ovarian tissue, but may prefer to carry pregnancy to term after cancer treatment. The latter approach is a non-established concept needing both modern radiation therapy approaches as well as modifications -if at all possible- in current recommendations for target volume delineation to spare dose to the unaffected uterus. Future strategies to serve selected patients in this respect should only be conducted in prospective clinical evaluations and are critically discussed in this article.
接受放化疗的年轻宫颈癌患者可能对保留生育能力感兴趣，这不仅依赖于使用妊娠载体，比如通过卵巢移位和卵母细胞或卵巢组织的冷冻保存来实现，而且她们可能更倾向于在癌症治疗后足月妊娠。后一种方法是一个尚未确立的概念，既需要现代放疗方法，也需要在当前靶区勾画建议中尽可能进行调整，以避免对未受影响的子宫造成剂量照射。在这方面为特定患者提供服务的未来策略应该仅在前瞻性临床评估中进行，本文对此进行了批判性讨论。
