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蛋白激酶C（PKC）可能参与调节兔海马切片中电诱发的5-羟色胺（5-HT）释放。

Possible involvement of protein kinase C (PKC) in the regulation of electrically evoked serotonin (5-HT) release from rabbit hippocampal slices.

作者信息

Feuerstein T J, Allgaier C, Hertting G

机构信息

Institut für Pharmakologie und Toxikologie, Universität Freiburg, F.R.G.

出版信息

Eur J Pharmacol. 1987 Jul 23;139(3):267-72. doi: 10.1016/0014-2999(87)90583-8.

DOI:10.1016/0014-2999(87)90583-8
PMID:3666005
Abstract

Protein kinase C (PKC)-activating phorbol esters enhanced the electrically evoked 5-HT release from rabbit hippocampal slices preincubated with [3H]5-HT. The release was diminished by polymyxin B, an inhibitor of PKC. These results are compatible with a stimulatory effect of PKC on the 5-HT release induced by action potentials. The mutual effects of PKC affecting drugs on 5-HT release suggest a functional but not a competitive interaction. The attenuation or the enhancement of effects of 5-HT autoreceptor ligands at various 5-HT biophase concentrations found after PKC-affecting drugs are in line with the view that autoreceptor-mediated events are not directly influenced by the enzyme PKC.

摘要

蛋白激酶C（PKC）激活剂佛波酯增强了预先用[3H]5-羟色胺（5-HT）孵育的兔海马切片中电诱发的5-HT释放。该释放被PKC抑制剂多粘菌素B所减弱。这些结果与PKC对动作电位诱导的5-HT释放的刺激作用相一致。PKC作用药物对5-HT释放的相互影响表明是功能性而非竞争性相互作用。在PKC作用药物处理后，在不同5-HT生物相浓度下发现5-HT自身受体配体效应的减弱或增强，这与自身受体介导的事件不受PKC酶直接影响的观点相符。

相似文献

1
Possible involvement of protein kinase C (PKC) in the regulation of electrically evoked serotonin (5-HT) release from rabbit hippocampal slices.蛋白激酶C（PKC）可能参与调节兔海马切片中电诱发的5-羟色胺（5-HT）释放。
Eur J Pharmacol. 1987 Jul 23;139(3):267-72. doi: 10.1016/0014-2999(87)90583-8.
2
Protein kinase C activation and alpha 2-autoreceptor-modulated release of noradrenaline.蛋白激酶C激活与α2-自受体调节的去甲肾上腺素释放
Br J Pharmacol. 1987 Sep;92(1):161-72. doi: 10.1111/j.1476-5381.1987.tb11308.x.
3
Participation of protein kinase C and regulatory G proteins in modulation of the evoked noradrenaline release in brain.蛋白激酶C和调节性G蛋白参与调节脑内诱发去甲肾上腺素释放。
Cell Mol Neurobiol. 1988 Mar;8(1):105-14. doi: 10.1007/BF00712916.
4
Staurosporine counteracts the phorbol ester-induced enhancement of neurotransmitter release in hippocampus.星形孢菌素可对抗佛波酯诱导的海马体神经递质释放增强。
Arch Int Pharmacodyn Ther. 1988 Nov-Dec;296:232-45.
5
Phorbol ester-induced hippocampal long-term potentiation is counteracted by inhibitors of protein kinase C.
Exp Brain Res. 1988;71(1):227-30. doi: 10.1007/BF00247540.
6
Modulation of 5-HT release in the guinea-pig brain following long-term administration of antidepressant drugs.长期服用抗抑郁药物后豚鼠脑内5-羟色胺释放的调节
Br J Pharmacol. 1994 Oct;113(2):485-95. doi: 10.1111/j.1476-5381.1994.tb17015.x.
7
Phorbol-12,13-dibutyrate antagonizes while forskolin potentiates the presynaptic autoreceptor-mediated inhibition of [3H]-5-hydroxytryptamine release in rat hypothalamic slices.佛波醇-12,13-二丁酸酯起拮抗作用，而福斯高林则增强大鼠下丘脑切片中突触前自身受体介导的对[3H]-5-羟色胺释放的抑制作用。
Synapse. 1989;3(3):173-81. doi: 10.1002/syn.890030302.
8
Protein kinase C and presynaptic modulation of acetylcholine release in rabbit hippocampus.蛋白激酶C与兔海马体中乙酰胆碱释放的突触前调节
Br J Pharmacol. 1988 Mar;93(3):525-34. doi: 10.1111/j.1476-5381.1988.tb10307.x.
9
3,4-Diaminopyridine-induced noradrenaline release from CNS tissue as a model for action potential-evoked transmitter release: effects of phorbol ester.以3,4-二氨基吡啶诱导中枢神经系统组织释放去甲肾上腺素作为动作电位诱发递质释放的模型：佛波酯的作用
Eur J Pharmacol. 1989 Oct 4;169(1):115-23. doi: 10.1016/0014-2999(89)90823-6.
10
Polymyxin B, a selective inhibitor of protein kinase C, diminishes the release of noradrenaline and the enhancement of release caused by phorbol 12,13-butyrate.多粘菌素B是一种蛋白激酶C的选择性抑制剂，它能减少去甲肾上腺素的释放以及由佛波酯12,13 -丁酸酯引起的释放增强。
Naunyn Schmiedebergs Arch Pharmacol. 1986 Oct;334(2):218-21. doi: 10.1007/BF00505825.

引用本文的文献

1
The structural requirements for phorbol esters to enhance serotonin and acetylcholine release from rat brain cortex.佛波酯增强大鼠大脑皮层中血清素和乙酰胆碱释放的结构要求。
Br J Pharmacol. 1999 Jul;127(5):1177-89. doi: 10.1038/sj.bjp.0702627.
2
Protein kinase C and presynaptic modulation of acetylcholine release in rabbit hippocampus.蛋白激酶C与兔海马体中乙酰胆碱释放的突触前调节
Br J Pharmacol. 1988 Mar;93(3):525-34. doi: 10.1111/j.1476-5381.1988.tb10307.x.
3
A role for protein kinase C in the electrically evoked release of [3H] gamma-aminobutyric acid in rabbit caudate nucleus.
蛋白激酶C在兔尾状核中电诱发释放[3H]γ-氨基丁酸的作用。
Naunyn Schmiedebergs Arch Pharmacol. 1989 Mar;339(3):302-5. doi: 10.1007/BF00173582.
4
Involvement of adenylate cyclase and protein kinase C in the alpha 2-adrenoceptor-mediated inhibition of noradrenaline and 5-hydroxytryptamine release in rat hypothalamic slices.腺苷酸环化酶和蛋白激酶C参与α2 -肾上腺素能受体介导的大鼠下丘脑切片中去甲肾上腺素和5 -羟色胺释放的抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1989 Oct;340(4):386-95. doi: 10.1007/BF00167039.
5
Influence of phorbol esters on stimulation-induced noradrenaline release and contractile force of isolated guinea-pig atria.佛波酯对豚鼠离体心房刺激诱导的去甲肾上腺素释放及收缩力的影响。
Basic Res Cardiol. 1991 May-Jun;86(3):283-90. doi: 10.1007/BF02190608.
6
The role of protein kinase C and its neuronal substrates dephosphin, B-50, and MARCKS in neurotransmitter release.蛋白激酶C及其神经元底物去磷酸化蛋白、B-50和富含丙氨酸的豆蔻酰化蛋白激酶C底物在神经递质释放中的作用。
Mol Neurobiol. 1991;5(2-4):87-130. doi: 10.1007/BF02935541.