阿扎丙宗和别嘌醇对大鼠心肌梗死面积的影响。

Effect of azapropazone and allopurinol on myocardial infarct size in rats.

作者信息

Montor S G, Thoolen M J, Mackin W M, Timmermans P B

机构信息

Division of Cardiovascular Diseases, E.I. du Pont de Nemours & Company Inc., Wilmington, DE 19898.

出版信息

Eur J Pharmacol. 1987 Aug 11;140(2):203-7. doi: 10.1016/0014-2999(87)90806-5.

DOI:10.1016/0014-2999(87)90806-5

PMID:3666017

Abstract

The effect of the xanthine oxidase inhibitor allopurinol and the non-steroidal antiinflammatory agent azapropazone on infarct size in rats, subjected to 48 h of occlusion of the left anterior descending coronary artery, were studied. Allopurinol (50 mg/kg i.p., twice daily from 24 h before to 48 h after LAD occlusion) and azapropazone (100 mg/kg i.p twice daily from 24 h before to 48 h after LAD occlusion) significantly reduced infarct size when compared to saline-treated rats. These data point towards involvement of xanthine oxidase derived free radicals in evolving myocardial infarction in rats; beneficial effect of azapropazone in this model may be related to the drug's ability to inhibit xanthine oxidase as well as various key neutrophil functions.

摘要

研究了黄嘌呤氧化酶抑制剂别嘌呤醇和非甾体抗炎药阿扎丙宗对左冠状动脉前降支闭塞48小时大鼠梗死面积的影响。与生理盐水处理的大鼠相比，别嘌呤醇（腹腔注射50mg/kg，在左冠状动脉前降支闭塞前24小时至闭塞后48小时，每日两次）和阿扎丙宗（腹腔注射100mg/kg，在左冠状动脉前降支闭塞前24小时至闭塞后48小时，每日两次）显著减小了梗死面积。这些数据表明黄嘌呤氧化酶衍生的自由基参与了大鼠心肌梗死的发展过程；在该模型中阿扎丙宗的有益作用可能与其抑制黄嘌呤氧化酶以及多种关键中性粒细胞功能的能力有关。