Awad Kamal, Sayed Ahmed, Banach Maciej
Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Zagazig University Hospitals, Zagazig, Egypt.
Front Cardiovasc Med. 2022 Apr 15;9:857364. doi: 10.3389/fcvm.2022.857364. eCollection 2022.
Effective interventions that might limit myocardial ischemia-reperfusion (I/R) injury are still lacking. Coenzyme Q (CoQ) may exert cardioprotective actions that reduce myocardial I/R injury. We conducted this meta-analysis to assess the potential cardioprotective effect of CoQ in animal models of myocardial I/R injury.
We searched PubMed and Embase databases from inception to February 2022 to identify animal studies that compared the effect of CoQ with vehicle treatment or no treatment on myocardial infarct size in models of myocardial I/R injury. Means and standard deviations of the infarct size measurements were pooled as the weighted mean difference with 95% confidence interval (CI) using the random-effects model. Subgroup analyses were also conducted according to animals' species, models' type, and reperfusion time.
Six animal studies (4 and 2 ) with 116 animals were included. Pooled analysis suggested that CoQ significantly reduced myocardial infarct size by -11.36% (95% CI: -16.82, -5.90, < 0.0001, I = 94%) compared with the control group. The significance of the pooled effect estimate was maintained in rats, Hartley guinea pigs, and Yorkshire pigs. However, it became insignificant in the subgroup of rabbits -5.29% (95% CI: -27.83, 17.26; I = 87%). Furthermore, CoQ significantly reduced the myocardial infarct size regardless of model type (either or ) and reperfusion time (either ≤ 4 h or >4 h).
Coenzyme Q significantly decreased myocardial infarct size by 11.36% compared with the control group in animal models of myocardial I/R injury. This beneficial action was retained regardless of model type and reperfusion time.
目前仍缺乏可能限制心肌缺血再灌注（I/R）损伤的有效干预措施。辅酶Q（CoQ）可能具有减少心肌I/R损伤的心脏保护作用。我们进行了这项荟萃分析，以评估CoQ在心肌I/R损伤动物模型中的潜在心脏保护作用。
我们检索了从数据库建立至2022年2月的PubMed和Embase数据库，以确定将CoQ与载体治疗或不治疗对心肌I/R损伤模型中心肌梗死面积的影响进行比较的动物研究。使用随机效应模型将梗死面积测量的均值和标准差合并为加权平均差，并给出95%置信区间（CI）。还根据动物种类、模型类型和再灌注时间进行了亚组分析。
纳入了6项动物研究（4项大鼠研究和2项其他动物研究），共116只动物。汇总分析表明，与对照组相比，CoQ使心肌梗死面积显著减少了-11.36%（95%CI：-16.82，-5.90；P<0.0001，I²=94%）。在大鼠、哈特利豚鼠和约克夏猪中，汇总效应估计的显著性得以维持。然而，在兔子亚组中该效应变得不显著，为-5.29%（95%CI：-27.83，17.26；I²=87%）。此外，无论模型类型（结扎或缺血再灌注）和再灌注时间（≤4小时或>4小时）如何，CoQ均显著减小了心肌梗死面积。
在心肌I/R损伤动物模型中，与对照组相比，辅酶Q使心肌梗死面积显著减少了11.36%。无论模型类型和再灌注时间如何，这种有益作用均得以保持。
