Lu Jiongdi, Zheng Zhi, Ding Yixuan, Qu Yuanxu, Mei Wentong, Fang Zhen, Qu Chang, Feng Yulu, Guo Yulin, Gao Chongchong, Cao Feng, Li Fei
Clinical Center of Acute Pancreatitis, Capital Medical University, Beijing, People's Republic of China.
Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China.
J Inflamm Res. 2023 Jan 11;16:127-144. doi: 10.2147/JIR.S388305. eCollection 2023.
To clarify the incidence of colonic complications in patients with NP and their impact on prognosis.
The clinical data of NP patients admitted to the Department of General Surgery of Xuanwu Hospital, Capital Medical University from January 2014 to December 2020 were retrospectively analyzed. Patients were grouped according to the presence or absence of colonic complications, and the clinical prognosis of the two groups was analyzed after matching using a 1:1 propensity score, The primary study endpoint was patient mortality during hospitalization. Data are reported as median (range) or percentage of patients (%).
A total of 306 patients with NP were included in this study, and the incidence of colonic complications was 12.4%, including 15 cases of colonic obstruction, 17 cases of colonic fistula, and 9 cases of colonic hemorrhage. Before matching, patients in the colonic group had severe admissions and poor clinical outcomes (<0.05). After matching, the baseline data and clinical characteristics at admission were comparable between the two groups of patients. In terms of clinical outcomes, although the mortality was similar in the two groups (>0.05), but patients in the colonic group were more likely to have multiorgan failure, length of nutrition support, number of minimally invasive interventions, number of extra-pancreatic infections, length of ICU stay and total length of stay were significantly higher than those of patients in the group without colonic complications (<0.05). During long-term follow-up, patients in the colonic group were more likely to develop recurrent pancreatitis.
About 12.4% of NP patients developed colonic complications, and after PSM it was found that colonic complications only led to a longer hospital stay and an increased number of clinical interventions in NP patients and did not increase the mortality.
明确神经源性胰腺炎（NP）患者结肠并发症的发生率及其对预后的影响。
回顾性分析2014年1月至2020年12月首都医科大学宣武医院普通外科收治的NP患者的临床资料。根据是否存在结肠并发症对患者进行分组，并采用1:1倾向评分匹配后分析两组的临床预后，主要研究终点为患者住院期间的死亡率。数据以中位数（范围）或患者百分比（%）表示。
本研究共纳入306例NP患者，结肠并发症的发生率为12.4%，其中结肠梗阻15例，结肠瘘17例，结肠出血9例。匹配前，结肠并发症组患者入院病情严重，临床结局较差（P<0.05）。匹配后，两组患者入院时的基线数据和临床特征具有可比性。在临床结局方面，虽然两组患者的死亡率相似（P>0.05），但结肠并发症组患者更易发生多器官功能衰竭，营养支持时间、微创干预次数、胰腺外感染次数、重症监护病房（ICU）住院时间和总住院时间均显著高于无结肠并发症组患者（P<0.05）。在长期随访中，结肠并发症组患者更易发生复发性胰腺炎。
约12.4%的NP患者发生结肠并发症，倾向评分匹配后发现结肠并发症仅导致NP患者住院时间延长和临床干预次数增加，并未增加死亡率。
