Zalesov V S, Kolla V E, Khvolis E A
Farmakol Toksikol. 1987 Jul-Aug;50(4):15-8.
Effects of anticonvulsants (phenobarbital, hexamidine, benzonal, difenin, chloracon, trimetin, carbamazepine) on the psychotropic activity of tranquillizers (diazepam, chlordiazepoxide, meprotan, trioxazine, mebicar) were studied in experiments on mice and rats. Thirteen combinations were studied by using corazol test, "open field" and elementary-defensive conditioned response technique. According to all three tests the psychotropic activity was enhanced to the greatest degree by administration of hexamidine in combination with chlordiazepoxide.
在小鼠和大鼠实验中,研究了抗惊厥药(苯巴比妥、己脒定、苯佐那尔、二苯乙内酰脲、氯拉克酮、三甲双酮、卡马西平)对镇静剂(地西泮、氯氮卓、美普他酮、三氧二氮、美比卡)精神活性的影响。通过使用戊四氮试验、“旷场”试验和基本防御条件反应技术,对13种组合进行了研究。根据所有这三项试验,己脒定与氯氮卓联合给药时,精神活性增强的程度最大。