Zalesov V S, Kolla V E, Khvolis E A
Farmakol Toksikol. 1985 Jul-Aug;48(4):25-8.
Experiments on mice were made to study anticonvulsive activity of the combinations of 5 tranquilizers (diazepam, chlorodiazepoxide, meprotan, trioxazin, mebicar) and 7 anticonvulsants (phenobarbital, hexamidine, benzonal, diphenin, chloracon, trimetin, carbamazepin) according to the maximal electroshock test. The data obtained form an experimental basis for the combined use of some anticonvulsants and tranquilizers in the treatment of epilepsy, since in a number of cases these combinations permit a significant lowering of the doses of both components without reducing their anticonvulsant activity.
根据最大电休克试验，在小鼠身上进行了实验，以研究5种镇静剂（地西泮、氯氮卓、甲丙氨酯、三氧二氮、美比卡）和7种抗惊厥药（苯巴比妥、己脒定、苯佐那尔、苯妥英、氯拉克酮、三甲双酮、卡马西平）组合的抗惊厥活性。所获得的数据为某些抗惊厥药和镇静剂联合用于治疗癫痫提供了实验依据，因为在许多情况下，这些组合能够在不降低其抗惊厥活性的情况下，显著降低两种成分的剂量。
