Burov Iu V, Ostrovskaia R U, Smol'nikova N M, Trofimov S S, Savchenko N M
Farmakol Toksikol. 1987 Jul-Aug;50(4):18-22.
Changes in the central nervous system activity caused by an early postnatal (7th day of life) injection of cycloheximide (CHX) were studied during experiments on adult rats. Disturbances in the process of learning in the experiments on conditioned reflexes of active and passive avoidance, difficulties in solving the extrapolatory task, weakening of habituation, motor hyperactivity, disorder of movement coordination were noted. Electrophysiological analysis by means of evoked potential recovery cycles revealed deficiency of GABAergic inhibition in the cerebral cortex. Hydroxybutyric salts of sodium and lithium as well as piracetam injected after CHX (from 8th through 14th days of life) normalized general behavior and learning capability of adult rats. Phenibut (beta-phenyl-GABA) was inferior by its efficacy, GABA exhibited no distinct effect.
在成年大鼠实验中，研究了出生后早期（出生后第7天）注射环己酰亚胺（CHX）引起的中枢神经系统活动变化。在主动和被动回避条件反射实验中发现学习过程受到干扰，解决推断任务存在困难，习惯化减弱，运动活动亢进，运动协调障碍。通过诱发电位恢复周期进行的电生理分析显示大脑皮层中γ-氨基丁酸能抑制作用不足。在CHX注射后（出生后第8天至14天）注射的钠和锂的羟基丁酸盐以及吡拉西坦使成年大鼠的一般行为和学习能力恢复正常。苯乙胺（β-苯基-γ-氨基丁酸）的疗效较差，γ-氨基丁酸未表现出明显效果。
