Mashkovskiĭ M D, Roshchina L F, Polezhaeva A I
Farmakol Toksikol. 1977 Nov-Dec;40(6):676-83.
As concerns most generally accepted characteristics adopted in pharmacological studies of psychotropic drugs pyracetam is little active, has no effect on the EEG of the cortex and subcortical structures of the brain. At the same time, in a number of tests this drug displayed a well-marked influence on the central nervous system. It restrains convulsive activity provoked by application to the cerebral cortex of strychnine and penicillin solutions, reduces EEG disturbances produced by barbiturates poisoning and acute hypoxia of the brain. Pyracetam also facilitates the process of teaching in rats, improves the execution of a developed conditioned avoidance reaction, protects rats against manifestations of retrograde amnesia induced by an electric shock, applied after development of the conditioned reflex of passive avoidance.
就精神药物药理学研究中采用的最普遍认可的特性而言，吡拉西坦活性很低，对大脑皮层和皮层下结构的脑电图没有影响。与此同时，在多项试验中，这种药物对中枢神经系统表现出显著影响。它能抑制将士的宁和青霉素溶液应用于大脑皮层所引发的惊厥活动，减轻巴比妥类药物中毒和大脑急性缺氧所产生的脑电图紊乱。吡拉西坦还能促进大鼠的学习过程，改善已形成的条件性回避反应的执行情况，保护大鼠免受在被动回避条件反射形成后施加的电击所诱发的逆行性遗忘症状的影响。
