Department of Pharmacy, The Affiliated Xiangshan Hospital of Wenzhou Medical University, Zhejiang, 315700, Ningbo, China.
Chemical Biology Research Center, School of Pharmacological Sciences, Wenzhou Medical University, Zhejiang, 325035, Wenzhou, China.
Cardiovasc Drugs Ther. 2024 Jun;38(3):555-568. doi: 10.1007/s10557-023-07426-3. Epub 2023 Jan 20.
Diabetic cardiomyopathy (DCM) is a common and severe complication of diabetes. Inflammation and oxidative stress play important roles in DCM development. Bicyclol is a hepatoprotective drug in China that exerts anti-inflammatory effects by inhibiting the MAPK and NF-κB pathways to prevent obesity-induced cardiomyopathy. Our purpose was to explore the effect and mechanism of bicyclol on DCM.
A type 1 diabetes mouse model was established using C57BL/6 mice by intraperitoneal injection of STZ. The therapeutic effect of bicyclol was evaluated in both heart tissues of diabetic mice and high concentration of glucose (HG)-stimulated H9c2 cells.
We showed that bicyclol significantly attenuated diabetes-induced cardiac hypertrophy and fibrosis, which is accompanied by the preservation of cardiac function in mice. In addition, bicyclol exhibited anti-inflammatory and anti-oxidative effects both in vitro and in vivo. Furthermore, bicyclol inhibited the hyperglycemia-induced activation of MAPKs and NF-κB pathways, while upregulating the Nrf-2/HO-1 pathway to exhibit protective effects.
Our data indicate that bicyclol could be a promising cardioprotective agent in the treatment of DCM.
糖尿病心肌病（DCM）是糖尿病的一种常见且严重的并发症。炎症和氧化应激在 DCM 的发展中起重要作用。双环醇是中国的一种保肝药物，通过抑制 MAPK 和 NF-κB 途径发挥抗炎作用，预防肥胖诱导的心肌病。我们的目的是探讨双环醇对 DCM 的作用及其机制。
通过腹腔注射 STZ 建立 C57BL/6 小鼠 1 型糖尿病模型。在糖尿病小鼠的心脏组织和高浓度葡萄糖（HG）刺激的 H9c2 细胞中评估双环醇的治疗效果。
我们表明，双环醇可显著减轻糖尿病引起的心脏肥大和纤维化，同时保护小鼠的心脏功能。此外，双环醇在体外和体内均表现出抗炎和抗氧化作用。此外，双环醇抑制高血糖诱导的 MAPKs 和 NF-κB 途径的激活，同时上调 Nrf-2/HO-1 途径发挥保护作用。
我们的数据表明，双环醇可能是治疗 DCM 的一种有前途的心脏保护剂。
