Miyake A, Yoshimoto Y, Hirota K, Wakimoto H, Terakawa N, Aono T, Tanizawa O
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
Eur J Obstet Gynecol Reprod Biol. 1987 Sep;26(1):19-25. doi: 10.1016/0028-2243(87)90005-0.
To study the effect of clomiphene citrate (clomiphene) administration during the early luteal phase of the menstrual cycle on the luteal function and the pregnancy rate in women, 75 infertile women who ovulated but did not conceive after clomiphene treatment during the early follicular phase and 6 normal cycling women were chosen. Clomiphene was administered orally to 35 of the 75 infertile women at a dose of 50 mg per day for 5 days from the second day of the rise in the basal body temperature (BBT) as well as during the follicular phase, while 40 control patients received clomiphene only during the follicular phase. In the test patients, the rate of pregnancy (25.7%) was significantly (p less than 0.05) higher than that of control patients (10.0%). On the 7th of the rise of BBT, the mean serum progesterone levels of the test patients and normal cycling women treated with clomiphene were significantly (p less than 0.05) higher than those of the control patients. However, the levels of serum estradiol, LH and FSH, the gonadotropin pulsatilities, and the pituitary responses to LH-RH in the test women were not significantly different from those of the control. These data suggest that, when administered during the early luteal phase, clomiphene may act directly on the ovary, enhancing the secretion of progesterone from the corpus luteum, and thereby increasing the rate of pregnancy in infertile women with clomiphene-induced ovulation.
为研究在月经周期黄体期早期给予枸橼酸氯米芬（克罗米芬）对女性黄体功能及妊娠率的影响，选取了75名在卵泡期早期接受克罗米芬治疗后排卵但未受孕的不孕女性以及6名月经周期正常的女性。在75名不孕女性中，35名从基础体温（BBT）上升的第二天起以及在卵泡期期间，每天口服50毫克克罗米芬，持续5天，而40名对照患者仅在卵泡期接受克罗米芬治疗。在试验组患者中，妊娠率（25.7%）显著高于对照组患者（10.0%）（p<0.05）。在BBT上升的第7天，接受克罗米芬治疗的试验组患者和正常月经周期女性的平均血清孕酮水平显著高于对照组患者（p<0.05）。然而，试验组女性的血清雌二醇、促黄体生成素（LH）和促卵泡生成素（FSH）水平、促性腺激素脉冲分泌以及垂体对促黄体生成素释放激素（LH-RH）的反应与对照组无显著差异。这些数据表明，在黄体期早期给予克罗米芬时，它可能直接作用于卵巢，增强黄体分泌孕酮，从而提高克罗米芬诱导排卵的不孕女性的妊娠率。
