普鲁卡因和咖啡因对酶分离心肌细胞及完整心脏组织收缩性的影响。
Effects of procaine and caffeine on the contractility of enzymatically isolated myocytes and intact cardiac tissue.
作者信息
Vornanen M
机构信息
Department of Biology, University of Joensuu, Finland.
出版信息
Gen Pharmacol. 1987;18(6):599-604. doi: 10.1016/0306-3623(87)90030-9.
PMID:3666397
Abstract
- Procaine and caffeine exerted opposite effects on the contractility of rat cardiac tissue. 2. Procaine enhanced and caffeine depressed isometric contractile force of right ventricular strips. 3. In enzymatically isolated cells, caffeine increased the frequency and decreased the amplitude of spontaneous contractions, while procaine retarded the beating rate but concomitantly raised the shortening amplitude of the myocyte. 4. Both drugs depressed the propagation velocity of the contractile waves. 5. The results are suggested to be due to the opposite effects of the two drugs on the Ca-release process of the sarcoplasmic reticulum.
摘要
- 普鲁卡因和咖啡因对大鼠心脏组织的收缩性产生相反的作用。2. 普鲁卡因增强而咖啡因降低右心室条带的等长收缩力。3. 在酶分离的细胞中，咖啡因增加自发收缩的频率并降低其幅度，而普鲁卡因减慢搏动速率但同时提高心肌细胞的缩短幅度。4. 两种药物均降低收缩波的传播速度。5. 结果提示这两种药物对肌浆网钙释放过程的相反作用所致。
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