Smiddy W E, Green W R
Wilmer Ophthalmological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
Graefes Arch Clin Exp Ophthalmol. 1987;225(5):321-4. doi: 10.1007/BF02153397.
During a 10-year period ending in 1985, we observed atrophy of the maculopapillary bundle in both eyes of 25 cases examined post mortem. We retrospectively examined the clinical history and general autopsy findings for evidence of malnutrition. An adequate clinical history was obtained in 24 patients, and an autopsy was performed on 21 patients. Our review disclosed that all 25 patients had marked nutritional deprivation, most commonly from alcohol abuse (20 patients), advanced carcinoma (8 patients, 7 of whom were also alcohol abusers), and other malnutritional and disabling conditions (4 patients). A history of heavy smoking was documented in 11 patients. Our findings support the contention that dietary deficiency plays a role in the pathogenesis of the condition that in the past has been referred to as tobacco-alcohol amblyopia and more recently has been called nutritional amblyopia.
在截至1985年的10年期间，我们对25例死后检查的病例进行观察，发现其双眼的视乳头黄斑束萎缩。我们回顾性地检查了临床病史和尸检结果，以寻找营养不良的证据。24例患者有完整的临床病史，21例患者接受了尸检。我们的回顾发现，所有25例患者均有明显的营养缺乏，最常见的原因是酗酒（20例）、晚期癌症（8例，其中7例也是酗酒者）以及其他营养不良和致残性疾病（4例）。11例患者有大量吸烟史。我们的研究结果支持了这样的观点，即饮食缺乏在这种疾病的发病机制中起作用，这种疾病过去被称为烟酒性弱视，最近被称为营养性弱视。
