Cressent M, Elie C, Milhaud G
Faculté de Médecine Saint-Antoine, Laboratoire de Biophysique, Paris, France.
Horm Metab Res. 1987 Aug;19(8):364-6. doi: 10.1055/s-2007-1011825.
The effect of calcitonin (CT) on the prolactin (PRL) surge of proestrus in rats was investigated under normal and perturbed lighting conditions. Salmon calcitonin (SCT) was injected i.p. on diestrus 2 or on proestrus, plasma PRL levels were measured by radioimmunoassay. SCT had no effect on the PRL surge under normal lighting conditions but it induced a small drop in PRL level measured on proestrus morning, 3 hours after CT injection. Animals submitted to perturbed light conditions had higher PRL levels than those kept under normal lighting. These data would indicate that for the female rats on proestrus the sensitivity to stress due to injection and blood sampling may be modulated by changing the photoperiod. SCT injection under these conditions may facilitate this destabilization in PRL level.
在正常和光照条件受干扰的情况下，研究了降钙素（CT）对大鼠发情前期催乳素（PRL）激增的影响。在动情间期第2天或发情前期腹腔注射鲑鱼降钙素（SCT），通过放射免疫测定法测量血浆PRL水平。在正常光照条件下，SCT对PRL激增没有影响，但在CT注射后3小时，即发情前期早晨测量时，它导致PRL水平略有下降。处于光照条件受干扰环境的动物的PRL水平高于处于正常光照环境的动物。这些数据表明，对于发情前期的雌性大鼠，注射和采血引起的应激敏感性可能会因光周期的改变而受到调节。在这些条件下注射SCT可能会促进PRL水平的这种不稳定。
