Olgiati V R, Netti C, Guidobono F, Pecile A
Endocrinology. 1982 Aug;111(2):641-4. doi: 10.1210/endo-111-2-641.
The effects of intracerebroventricular (icv;25ng/rat) or iv (10 micrograms/kg) salmon calcitonin (sCT) on PRL secretion were determined in lactating rats and compared to the effects in intact or ovariectomized-estrogen-treated female rats. The icv or iv injections of sCT 9 days after estrogen treatment did not significantly lower the PRL levels in intact rats. In ovariectomized-estrogen-primed animals, sCT (icv or iv) did not modify the afternoon surge of PRL secretion when injected during the surge, nor did it delay or attenuate the increasing secretory activity when administered (iv) before the afternoon surge had begun. On the contrary, 30 or 60 min after the icv or iv administration of sCT to lactating rats, suckling-induced PRL secretion was prevented. These results and our previous evidence that a greater dose of sCT is needed to decrease the less intense morphine- or stress-induced PRL secretion indicate differential hypoprolactinemic properties of sCT, which are particularly striking during lactation. While the mechanisms underlying these selective activities deserve further investigation, the proposed participation of PRL in the regulation of calcium metabolism during lactation suggests that the potent PRL inhibitory effect of CT in this condition should be regarded as one factor in the complex mechanism that prevents bone loss and protects the maternal skeleton.
在哺乳期大鼠中测定了脑室内（icv；25 ng/大鼠）或静脉内（iv；10微克/千克）注射鲑鱼降钙素（sCT）对催乳素（PRL）分泌的影响，并与完整或去卵巢-雌激素处理的雌性大鼠中的影响进行了比较。雌激素处理9天后icv或iv注射sCT并未显著降低完整大鼠的PRL水平。在去卵巢-雌激素预处理的动物中，sCT（icv或iv）在PRL分泌高峰期间注射时不会改变下午的PRL分泌高峰，在下午高峰开始前静脉注射时也不会延迟或减弱分泌活性的增加。相反，对哺乳期大鼠icv或iv注射sCT后30或60分钟，吸吮诱导的PRL分泌受到抑制。这些结果以及我们之前的证据表明，需要更大剂量的sCT才能降低强度较低的吗啡或应激诱导的PRL分泌，这表明sCT具有不同的催乳素降低特性，在哺乳期尤为显著。虽然这些选择性活性的潜在机制值得进一步研究，但PRL参与哺乳期钙代谢调节的观点表明，CT在这种情况下对PRL的有效抑制作用应被视为预防骨质流失和保护母体骨骼的复杂机制中的一个因素。
