Lee Kuan-I, Lin Jing-Hua, Chu Yen-Jung, Deng Jou-Fang, Chu Wei-Lan, Hung Dong-Zong
Department of Emergency, Buddhist Tzu Chi General Hospital, Taichung Branch, Taichung 42721, Taiwan.
Division of Toxicology, China Medical University Hospital, Taichung 40447, Taiwan.
Toxics. 2023 Jan 8;11(1):60. doi: 10.3390/toxics11010060.
Bromadiolone, a potent, long-acting anticoagulant rodenticide is frequently tinted to a red or pink color and mixed with cereals as rat bait. Six peoples working in a small factory suffered from a severe bleeding tendency several weeks after consuming a rice meal that was tainted with bromadiolone mistaken to be healthy food. High serum levels of bromadiolone and excessive bleeding were found in these individuals, and they needed vitamin K1 therapy for weeks. These cases indicated that long-acting anticoagulant rodenticide might induce cumulative toxicity in repeated, low-dose exposure, and the blood levels of bromadiolone might be an indicator for antidote therapy if available.
溴敌隆是一种强效、长效抗凝血灭鼠剂，常被染成红色或粉红色，并与谷物混合作为鼠饵。一家小工厂的六名工人在食用了被误认为是健康食品但被溴敌隆污染的米饭几周后，出现了严重的出血倾向。这些人血清中溴敌隆水平很高且有过度出血症状，他们需要接受数周的维生素K1治疗。这些案例表明，长效抗凝血灭鼠剂在反复低剂量接触时可能会引发累积毒性，并且如果有解毒剂治疗，溴敌隆的血液水平可能是其指标。
