Chu Yen-Jung, Lin Jing-Hua, Hung Dong-Zong
Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan.
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Biomedicine (Taipei). 2022 Jun 1;12(2):47-49. doi: 10.37796/2211-8039.1305. eCollection 2022.
Brodifacoum is a highly potent and long-acting anticoagulant rodenticide (LAAR). LAAR poisoning possibly leads to long term bleeding problems and needs vitamin K1 treatment for several months. Due to economic concern, tablet preparation of vitamin K1 was not available in most of the countries, including Taiwan. In literature, few reports had pointed out that injectable form of vitamin K could be used orally in patients on anticoagulant therapy with supratherapeutic state. Here, we reported a family with 3 members suffering from brodifacoum poisoning with severe coagulopathy needed to prolong hospitalization for intravenous vitamin K1 therapy, and successfully managed with injectable formula orally for about 5 months. Oral administration of injectable vitamin K1 might be a suitable substitute for intravenous route in long-term treatment for LAAR poisonings.
溴敌隆是一种高效长效抗凝血灭鼠剂（LAAR）。LAAR中毒可能导致长期出血问题，需要使用维生素K1治疗数月。出于经济方面的考虑，包括台湾地区在内的大多数国家都没有维生素K1片剂制剂。在文献中，很少有报道指出，在接受超治疗剂量抗凝治疗的患者中，维生素K的注射剂型可口服使用。在此，我们报告了一个有3名成员的家庭，他们因溴敌隆中毒并伴有严重凝血障碍，需要延长住院时间接受静脉注射维生素K1治疗，最终成功地口服注射用配方药物约5个月。口服注射用维生素K1可能是LAAR中毒长期治疗中静脉注射途径的合适替代方法。
