Tripathi R M, Kaushal R, Veeranjaneyulu A
Department of Pharmacology, IDPL Research Centre, Hyderabad.
Indian J Physiol Pharmacol. 1987 Apr-Jun;31(2):111-6.
ST-93, a clonidine analog was studied for its antiarrhythmic activity in anaesthetised guinea pigs against ouabain induced arrhythmia. The amount of ouabain required (micrograms/kg) for the production of ventricular premature best. Ventricular fibrillation and cardiac arrest was recorded in control and drug treated group of animals. Both ST-93 and clonidine produced significant antiarrhythmic effect in guinea pigs. This protective effect was significantly blocked by yohimbine, suggesting that the antiarrhythmic effect is mediated through presynaptic alpha 2-adrenoceptors.
研究了可乐定类似物ST - 93在麻醉豚鼠中对抗哇巴因诱导的心律失常的抗心律失常活性。记录了对照组和药物治疗组动物产生室性早搏、心室颤动和心脏骤停所需的哇巴因量（微克/千克）。ST - 93和可乐定在豚鼠中均产生了显著的抗心律失常作用。育亨宾可显著阻断这种保护作用，提示抗心律失常作用是通过突触前α2 - 肾上腺素能受体介导的。
