一种有前景的能够降解中性粒细胞胞外诱捕网的生物分子：PDE，响尾蛇磷酸二酯酶。
A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: PDE, a Rattlesnake Phosphodiesterase.
机构信息
Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-903, SP, Brazil.
Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
出版信息
Toxins (Basel). 2023 Jan 5;15(1):44. doi: 10.3390/toxins15010044.
Neutrophil extracellular traps (NETs) are an important mechanism for defense against pathogens. Their overproduction can be harmful since excessive NET formation promotes inflammation and tissue damage in several diseases. Nucleases are capable to degrade NET on basis of their DNA hydrolysis activity, including the PDE, a nuclease isolated from snake venom. Here, we report a new finding about PDE activity, demonstrating its efficiency in degrading cell-free DNA from NETs, being a potential candidate to assist in therapies targeting inflammatory diseases.
中性粒细胞胞外陷阱 (NETs) 是防御病原体的重要机制。它们的过度产生可能是有害的，因为过量的 NET 形成会促进几种疾病中的炎症和组织损伤。核酸酶能够基于其 DNA 水解活性来降解 NET，其中包括从蛇毒中分离出的 PDE 核酸酶。在这里，我们报告了关于 PDE 活性的一个新发现，证明了其在降解 NET 中无细胞 DNA 的效率，是一种有潜力的候选物，可以辅助针对炎症性疾病的治疗。
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