委内瑞拉首例猴痘病例：部分完整基因组序列使其被归类为西非分支II。

First Case of Monkeypox in Venezuela: Partial Complete Genome Sequence Allowed Its Grouping into the West African Clade II.

作者信息

D'Angelo Pierina, Loureiro Carmen L, Jaspe Rossana C, Sulbaran Yoneira F, Rodríguez Lieska, Alarcón Víctor, García José Manuel, Zambrano José Luis, Liprandi Ferdinando, Rangel Héctor R, Pujol Flor H

机构信息

Dirección de Diagnóstico y Vigilancia de Enfermedades Transmisibles, Instituto Nacional de Higiene "Rafael Rangel", Caracas 1041, Venezuela.

Laboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas 1020, Venezuela.

出版信息

Trop Med Infect Dis. 2022 Dec 21;8(1):2. doi: 10.3390/tropicalmed8010002.

DOI:10.3390/tropicalmed8010002

PMID:36668909

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9864145/

Abstract

The ongoing epidemic of monkeypox virus (MPXV) infection has already reached more than 50,000 persons worldwide until the end of August 2022. We report the first case detected in Venezuela. The patient reported traveling from Spain and contact with friends tested positive for MPXV after his return. Partial complete genome phylogenetic analysis allowed to group the isolate within the clade II of MPXV, the major one circulating worldwide. No other case of MPXV has been detected until the end of August 2022 in the country, although the presence of undiagnosed cases due to the fear of stigmatization cannot be ruled out.

摘要

截至2022年8月底，猴痘病毒（MPXV）感染的持续流行已导致全球超过5万人感染。我们报告了在委内瑞拉发现的首例病例。该患者报告称从西班牙旅行归来，回国后其接触的朋友经检测MPXV呈阳性。部分全基因组系统发育分析将该分离株归为MPXV进化枝II，这是全球主要流行的进化枝。截至2022年8月底，该国未检测到其他MPXV病例，不过由于担心被污名化，不能排除存在未确诊病例的可能性。