Nutrition and Obesities: Systemic Approaches Research Group, NutriOmics, Sorbonne Université, INSERM, Paris, France.
Clinical Research Center, Medical University of Bialystok, Bialystok, Poland.
Diabetes. 2023 Feb 1;72(2):159-169. doi: 10.2337/db22-0676.
Hyaluronic acid, or hyaluronan (HA), is a nonsulfated glucosaminoglycan that has long been recognized for its hydrophilic properties and is widely used as a dermal filler. Despite much attention given to the study of other extracellular matrix (ECM) components, in the field of ECM properties and their contribution to tissue fibroinflammation, little is known of HA's potential role in the extracellular milieu. However, recent studies suggest that it is involved in inflammatory response, diet-induced insulin resistance, adipogenesis, and autoimmunity in type 1 diabetes. Based on its unique physical property as a regulator of osmotic pressure, we emphasize underestimated implications in adipose tissue function, adipogenesis, and obesity-related dysfunction.
透明质酸，或透明质酸钠（HA），是一种非硫酸化氨基葡萄糖聚糖，其亲水性早已得到认可，被广泛用作真皮填充剂。尽管人们对其他细胞外基质（ECM）成分的研究给予了很多关注，但在 ECM 特性及其对组织纤维化炎症的贡献方面，对 HA 在细胞外环境中的潜在作用知之甚少。然而，最近的研究表明，它参与了 1 型糖尿病中的炎症反应、饮食诱导的胰岛素抵抗、脂肪生成和自身免疫。基于其作为渗透压调节剂的独特物理特性，我们强调其在脂肪组织功能、脂肪生成和肥胖相关功能障碍方面被低估的影响。
