Sleep and Functional Neurobiology Laboratory, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile; Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile.
Sleep and Functional Neurobiology Laboratory, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.
Nutrition. 2023 Apr;108:111962. doi: 10.1016/j.nut.2022.111962. Epub 2022 Dec 31.
Experimental studies under laboratory conditions have shown a close link between acute sleep restriction and metabolic disorders. The aim of this study was to assess the effect of a single night of moderate sleep restriction implemented under ambulatory settings on sleep organization, food intake, blood pressure, and heart rate in overweight young adults.
In a non-randomized experimental study, we evaluated 15 young, overweight adults (mean age [± SEM] 20.8 ± 0.6 y) with a mean body mass index (BMI) 27.5 ± 6.2 kg/m (BMI range 18.9-36.6 kg/m). Each participant was recorded at home during two successive nights under: 1) Regular sleep routine (from 2330 to 0730 h, 'night1') and 2) Restricted sleep (6 h in bed, from 0300 to 0900 h, "night2"). Sleep was assessed by a non-invasive mobile system (Watch-PAT200) placed on the non-dominant wrist, measuring peripheral arterial tonometry. We measured sleep duration, rapid eye movement sleep (REM), light sleep (LS), deep sleep (DS), and waking. Starting 2 d before night1, four consecutive food records assessed daily food intake. Preceding and succeeding each night, hunger/satiety feelings (measured by self-reported visual analog scales), blood pressure, and heart rate were also evaluated.
Total sleep time was reduced in night2 (P = 0.007), with higher DS percentage (P = 0.03). Sleep onset and REM sleep latencies, LS time, and the number of wake episodes did not differ between nights. Energy intake was increased the day after night2 (P = 0.007), with increased fat and protein intakes (both P < 0.01) and feelings of hunger (P = 0.002). Systolic blood pressure was higher and heart rate faster in the morning after night2 (both P < 0.05).
An acute moderate at-home sleep restriction exacerbated food intake and feelings of hunger, and impaired blood pressure and heart rate regulation in young, overweight adults.
实验室条件下的实验研究表明，急性睡眠限制与代谢紊乱密切相关。本研究旨在评估在门诊环境下实施的单次适度睡眠限制对超重年轻成年人的睡眠结构、食物摄入、血压和心率的影响。
在一项非随机实验研究中，我们评估了 15 名年轻超重成年人（平均年龄[±SEM]20.8±0.6 岁），平均体重指数（BMI）为 27.5±6.2kg/m（BMI 范围 18.9-36.6kg/m）。每位参与者在连续两个晚上在家中记录：1）常规睡眠程序（从 23:30 到 07:30，“晚上 1 天”）和 2）睡眠限制（卧床 6 小时，从 03:00 到 09:00，“晚上 2 天”）。睡眠通过放置在非优势手腕上的非侵入性移动系统（Watch-PAT200）进行评估，测量外周动脉张力。我们测量了睡眠持续时间、快速眼动睡眠（REM）、浅睡眠（LS）、深睡眠（DS）和觉醒。在晚上 1 天之前的 2 天，连续 4 天记录评估每日食物摄入量。在每个晚上之前和之后，还评估了饥饿/饱腹感（通过自我报告的视觉模拟量表测量）、血压和心率。
晚上 2 天的总睡眠时间减少（P=0.007），DS 百分比更高（P=0.03）。睡眠潜伏期和 REM 睡眠时间、LS 时间和觉醒次数在两个晚上之间没有差异。晚上 2 天后的能量摄入增加（P=0.007），脂肪和蛋白质摄入增加（均 P<0.01），饥饿感增加（P=0.002）。晚上 2 天后的早晨，收缩压升高，心率加快（均 P<0.05）。
在家中进行急性适度睡眠限制会加重超重年轻成年人的食物摄入和饥饿感，并损害血压和心率调节。
