SMARCA4 缺陷型 H3K27M 弥漫中线脑胶质瘤：致命疾病的“银弹”。

SMARCA4 vulnerability in H3K27M midline glioma: A silver bullet for a lethal disease.

机构信息

Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.

Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada; Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.

出版信息

Mol Cell. 2023 Jan 19;83(2):163-164. doi: 10.1016/j.molcel.2022.12.028.

DOI:10.1016/j.molcel.2022.12.028

PMID:36669477

Abstract

To investigate epigenetic dependencies and identify therapeutic vulnerabilities, Mo et al. and Panditharatna et al. performed CRISPR screens and show that deadly H3K27M gliomas are dependent on mammalian BAF (SWI/SNF) chromatin remodeling complex.

摘要

为了研究表观遗传学的依赖性并确定治疗靶点的脆弱性，Mo 等人和 Panditharatna 等人进行了 CRISPR 筛选，结果表明致命的 H3K27M 神经胶质瘤依赖于哺乳动物的 BAF（SWI/SNF）染色质重塑复合物。