Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand; Genetics Otago, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand; Genetics Otago, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand; Bioprotection Aotearoa, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
Mol Cell. 2023 Jan 19;83(2):165-166. doi: 10.1016/j.molcel.2022.12.020.
Zhang et al. reveal a previously unknown route to toxin activation whereby bacteriophage capsid proteins bind the antitoxin domain of the CapRel fused toxin-antitoxin system, triggering translational inhibition via pyrophosporylation of tRNAs and culminating in abortive infection-mediated phage resistance.
张等人揭示了一种以前未知的毒素激活途径，噬菌体衣壳蛋白结合融合毒素-抗毒素系统的抗毒素结构域，通过 tRNA 的焦磷酸化触发翻译抑制，最终导致感染失败介导的噬菌体抗性。
