Department of Cardiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Key Laboratory of Ultrasound in Cardiac Electrophysiology and Biomechanics of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
ESC Heart Fail. 2023 Apr;10(2):1454-1460. doi: 10.1002/ehf2.14291. Epub 2023 Jan 20.
Reports on the treatment of nonobstructive hypertrophic cardiomyopathy (HCM) and severe mitral valve regurgitation (MR) with transcatheter edge-to-edge repair (TEER) are rare. Herein, we present the case of a 68-year-old Chinese man with nonobstructive HCM admitted to our hospital with dyspnoea [New York Heart Association (NYHA) functional Class IV]. Transthoracic echocardiography indicated severe MR in addition to asymmetric hypertrophy of the left ventricle. Despite administering maximal medical therapy for heart failure, the symptoms were not alleviated; because of the high risk of open surgery, TEER was performed for MR. After 4 months of follow-up, the patient showed a significant improvement in symptoms. Herein, we also discuss and review the pathophysiology and treatment strategies for HCM patients with heart failure.
经导管缘对缘修复术治疗非梗阻性肥厚型心肌病合并重度二尖瓣反流的报道较为罕见。本文报告了一例 68 岁的中国男性非梗阻性肥厚型心肌病患者，因呼吸困难（纽约心脏病协会心功能分级 IV 级）就诊我院。经胸超声心动图显示除左心室不对称性肥厚外，还伴有重度二尖瓣反流。尽管给予心力衰竭的最大药物治疗，但症状并未缓解；由于开胸手术风险较高，因此对二尖瓣反流行经导管缘对缘修复术。随访 4 个月后，患者症状明显改善。本文还讨论并复习了心力衰竭的肥厚型心肌病患者的病理生理学和治疗策略。
