Taper H S, de Gerlache J, Lans M, Roberfroid M
Unité de Biochimie Toxicologique et Cancérologique, Université Catholique de Louvain, Brussels, Belgium.
Int J Cancer. 1987 Oct 15;40(4):575-9. doi: 10.1002/ijc.2910400424.
The influence on the survival of ascitic liver tumor (TLT)-bearing mice of combined vitamins C and K3 administered before or after a single i.p. dose of 6 different cytotoxic drugs, all commonly used in human cancer therapy, was investigated. Combined i.p. administration of these vitamins produced a distinct chemotherapy-potentiating effect for all drugs examined, especially when injected before chemotherapy. This potentiating treatment did not increase the general and organ toxicity that accompanies cancer chemotherapy. The possible generation of peroxides followed by membrane lipid alteration, DNase activation and DNA destruction by combined vitamin C and K3 in catalase-deficient cancer cells might be involved in the mechanisms of this selective potentiation.
研究了在腹腔注射6种不同细胞毒性药物（均常用于人类癌症治疗）单次给药之前或之后给予维生素C和K3联合用药对荷腹水肝癌（TLT）小鼠存活的影响。这些维生素联合腹腔给药对所有检测药物均产生了明显的化疗增强作用，尤其是在化疗前注射时。这种增强治疗并未增加癌症化疗伴随的全身和器官毒性。在过氧化氢酶缺陷的癌细胞中，维生素C和K3联合用药可能产生过氧化物，继而导致膜脂质改变、DNase激活和DNA破坏，这可能参与了这种选择性增强作用的机制。
