Department of Chemistry, Emory University, Atlanta, GA 30322, USA; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Department of Chemistry, Emory University, Atlanta, GA 30322, USA.
Trends Pharmacol Sci. 2023 Mar;44(3):134-136. doi: 10.1016/j.tips.2023.01.002. Epub 2023 Jan 18.
Protein arginine methyltransferase (PRMT)-5 is a prominent epigenetic regulator and therapeutic target. Recently, Krzyzanowski et al. identified stapled peptides that inhibit the interaction of PRMT5 with two of its adaptor proteins. This discovery creates opportunities for novel therapeutic development by selectively modulating PRMT5 activity.
蛋白质精氨酸甲基转移酶(PRMT)-5 是一种重要的表观遗传调控因子和治疗靶点。最近,Krzyzanowski 等人鉴定了一种订书肽,该肽能抑制 PRMT5 与其两种衔接蛋白的相互作用。这一发现为通过选择性调节 PRMT5 活性来开发新型治疗方法提供了机会。