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Taming PRMT5-adaptor protein interactions.
Trends Pharmacol Sci. 2023 Mar;44(3):134-136. doi: 10.1016/j.tips.2023.01.002. Epub 2023 Jan 18.
2
Development of Macrocyclic PRMT5-Adaptor Protein Interaction Inhibitors.
J Med Chem. 2022 Nov 24;65(22):15300-15311. doi: 10.1021/acs.jmedchem.2c01273. Epub 2022 Nov 15.
3
Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5-MEP50 Complex.
Chembiochem. 2021 Jun 2;22(11):1908-1914. doi: 10.1002/cbic.202100079. Epub 2021 Mar 31.
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NF90/NFAR (nuclear factors associated with dsRNA) - a new methylation substrate of the PRMT5-WD45-RioK1 complex.
Biol Chem. 2022 Aug 31;403(10):907-915. doi: 10.1515/hsz-2022-0136. Print 2022 Sep 27.
6
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
J Med Chem. 2021 Aug 12;64(15):11148-11168. doi: 10.1021/acs.jmedchem.1c00507. Epub 2021 Aug 3.
7
Molecular basis for substrate recruitment to the PRMT5 methylosome.
Mol Cell. 2021 Sep 2;81(17):3481-3495.e7. doi: 10.1016/j.molcel.2021.07.019. Epub 2021 Aug 5.
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Discovery and Biological Characterization of PRMT5:MEP50 Protein-Protein Interaction Inhibitors.
J Med Chem. 2022 Oct 27;65(20):13793-13812. doi: 10.1021/acs.jmedchem.2c01000. Epub 2022 Oct 7.
9
The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond.
Cell Mol Life Sci. 2015 Jun;72(11):2041-59. doi: 10.1007/s00018-015-1847-9. Epub 2015 Feb 7.
10
Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer.
Cancer Res. 2020 Nov 15;80(22):4904-4917. doi: 10.1158/0008-5472.CAN-20-1228. Epub 2020 Sep 30.

引用本文的文献

1
A review of the known MTA-cooperative PRMT5 inhibitors.
RSC Adv. 2024 Dec 17;14(53):39653-39691. doi: 10.1039/d4ra05497k. eCollection 2024 Dec 10.

本文引用的文献

1
Development of Macrocyclic PRMT5-Adaptor Protein Interaction Inhibitors.
J Med Chem. 2022 Nov 24;65(22):15300-15311. doi: 10.1021/acs.jmedchem.2c01273. Epub 2022 Nov 15.
2
Discovery and Biological Characterization of PRMT5:MEP50 Protein-Protein Interaction Inhibitors.
J Med Chem. 2022 Oct 27;65(20):13793-13812. doi: 10.1021/acs.jmedchem.2c01000. Epub 2022 Oct 7.
3
Molecular basis for substrate recruitment to the PRMT5 methylosome.
Mol Cell. 2021 Sep 2;81(17):3481-3495.e7. doi: 10.1016/j.molcel.2021.07.019. Epub 2021 Aug 5.
4
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
J Med Chem. 2021 Aug 12;64(15):11148-11168. doi: 10.1021/acs.jmedchem.1c00507. Epub 2021 Aug 3.
5
Posttranslational modifications in proteins: resources, tools and prediction methods.
Database (Oxford). 2021 Apr 7;2021. doi: 10.1093/database/baab012.
6
Protein arginine methylation: from enigmatic functions to therapeutic targeting.
Nat Rev Drug Discov. 2021 Jul;20(7):509-530. doi: 10.1038/s41573-021-00159-8. Epub 2021 Mar 19.
7
Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5-MEP50 Complex.
Chembiochem. 2021 Jun 2;22(11):1908-1914. doi: 10.1002/cbic.202100079. Epub 2021 Mar 31.
8
PRMT5 function and targeting in cancer.
Cell Stress. 2020 Jul 13;4(8):199-215. doi: 10.15698/cst2020.08.228.
9
Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level.
Cell Mol Life Sci. 2019 Aug;76(15):2917-2932. doi: 10.1007/s00018-019-03145-x. Epub 2019 May 23.
10
Adaptor proteins.
Oncogene. 2001 Oct 1;20(44):6270-2. doi: 10.1038/sj.onc.1204769.

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