Kim Hyungsoo, Ronai Ze'ev A
Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Cell Stress. 2020 Jul 13;4(8):199-215. doi: 10.15698/cst2020.08.228.
Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response. Here we discuss the function of PRMT5, a member of the nine-member PRMT family, in controlling oncogenic processes including tumor intrinsic, as well as extrinsic microenvironmental signaling pathways. We discuss PRMT5 effect on histone methylation and methylation of regulatory proteins including those involved in RNA splicing, cell cycle, cell death and metabolic signaling. In all, we highlight the importance of PRMT5 regulation and function in cancer, which provide the foundation for therapeutic modalities targeting PRMT5.
蛋白质甲基转移酶在众多调控通路中发挥关键作用，这些通路构成了癌症发生、发展及治疗反应的基础。在此，我们讨论PRMT5（PRMT家族九个成员之一）在控制致癌过程中的功能，这些过程包括肿瘤内在以及外在的微环境信号通路。我们探讨PRMT5对组蛋白甲基化以及调控蛋白甲基化的影响，这些调控蛋白包括参与RNA剪接、细胞周期、细胞死亡和代谢信号传导的蛋白。总之，我们强调PRMT5调控和功能在癌症中的重要性，这为靶向PRMT5的治疗方式提供了基础。
