Wangsuphachart V, Thomas D B, Koetsawang A, Riotton G
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle.
Int J Epidemiol. 1987 Sep;16(3):362-6. doi: 10.1093/ije/16.3.362.
A case-control study of invasive cervical cancer was conducted in Siriraj Hospital, Thailand, as part of a WHO-sponsored collaborative study of neoplasia and steroid contraceptives. Data from 189 histologically confirmed cases and 1023 randomly selected hospitalized controls who were recruited from October 1979 through March 1983 were analysed to identify risk factors for cervical cancer in Thai women, and to assess the effectiveness of Papanicolaou smears (Pap smears) in preventing invasive cervical cancer in Thailand. Variables that distinguish women at significantly increased risk of invasive cervical cancer, to whom preventive programmes should be directed, include a history of treatment for abnormal vaginal discharge (an indicator of vaginal or cervical infection), a history of venereal disease, and little or no education (an indicator of low socioeconomic status). Risk of invasive cervical cancer decreased significantly as the frequency of Pap smears increased, and was reduced by 75% in women who had at least one Pap smear per year.
作为世界卫生组织赞助的一项关于肿瘤形成与甾体类避孕药具的合作研究的一部分，泰国诗里拉吉医院开展了一项浸润性宫颈癌病例对照研究。分析了1979年10月至1983年3月期间招募的189例经组织学确诊的病例和1023例随机选取的住院对照的数据，以确定泰国女性宫颈癌的危险因素，并评估巴氏涂片在泰国预防浸润性宫颈癌的有效性。区分浸润性宫颈癌风险显著增加的女性（预防性项目应针对这些女性）的变量包括异常阴道分泌物治疗史（阴道或宫颈感染的指标）、性病病史以及很少或没有接受教育（社会经济地位低的指标）。随着巴氏涂片检查频率的增加，浸润性宫颈癌的风险显著降低，每年至少进行一次巴氏涂片检查的女性风险降低了75%。
