Landry Émilie Kate, Autmizguine Julie, Bérubé Sophie, Kraus Raphael, Métras Marie-Élaine, Lebel Denis, Litalien Catherine
The Rosalind & Morris Goodman Family Pediatric Formulations Centre of the CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Department of Pediatrics, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Children (Basel). 2023 Jan 11;10(1):147. doi: 10.3390/children10010147.
Despite ongoing international efforts, many drugs administered to children must be compounded from dosage forms designed for adults because they remain unavailable in commercial formulations that suit their needs. Even though oral drug compounding is common in pediatrics, the extent of this practice has not been well described in recent years. This cross-sectional and retrospective study was conducted at a Canadian university-affiliated, 484-bed, tertiary care pediatric hospital and its rehabilitation centre on two randomly selected days. A total of 606 hospitalized children with 5465 prescriptions were included. Overall, compounded drugs for enteral administration (CDEA) represented 13% of all prescriptions (enteral and parenteral) and 23% of prescriptions for enteral administration. Of the 390 prescribed drugs, 122 required compounding. CDEA were mostly liquids (n = 478 [67%]) and mainly included drugs of the central nervous (35%), cardiovascular (21%), and gastro-intestinal (12%) systems. Nearly half (N = 298 [49%]) of children had at least one CDEA prescribed in their medical file. Many CDEA are available as commercial products in other jurisdictions. Collaboration is needed between all stakeholders to make these drugs available to Canadian children.
尽管国际社会一直在努力，但许多给儿童使用的药物必须从为成人设计的剂型中调配，因为适合儿童需求的商业制剂仍然没有。尽管口服药物调配在儿科很常见，但近年来这种做法的程度尚未得到充分描述。这项横断面回顾性研究在加拿大一所大学附属的、拥有484张床位的三级护理儿童医院及其康复中心进行，研究时间为随机选择的两天。总共纳入了606名住院儿童的5465份处方。总体而言，肠内给药的调配药物（CDEA）占所有处方（肠内和肠外）的13%，占肠内给药处方的23%。在390种处方药中，122种需要调配。CDEA大多为液体（n = 478 [67%]），主要包括中枢神经（35%）、心血管（21%）和胃肠（12%）系统的药物。近一半（N = 298 [49%]）的儿童在其病历中有至少一种CDEA处方。许多CDEA在其他司法管辖区有商业产品可供使用。所有利益相关者之间需要开展合作，以便加拿大儿童能够获得这些药物。
