Venckunas Tomas, Brazaitis Marius, Snieckus Audrius, Mickevicius Mantas, Eimantas Nerijus, Subocius Andrejus, Mickeviciene Dalia, Westerblad Håkan, Kamandulis Sigitas
Institute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania.
Kaunas Hospital of the Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania.
Antioxidants (Basel). 2022 Dec 22;12(1):16. doi: 10.3390/antiox12010016.
Inactivity is known to induce muscle weakness, and chronically increased levels of reactive oxygen species (ROS) are proposed to have a central causative role in this process. Intriguingly, high-intensity interval training (HIIT), which involves bursts of high ROS production, can have positive effects in pathological conditions with chronically increased ROS. Here, young male volunteers were exposed to 3 weeks of unloading of the dominant leg followed by 3 weeks of resistance training without (Ctrl group) or with the addition of all-out cycling HIIT. Changes in muscle thickness were assessed by ultrasonography, and contractile function was studied by measuring the torque during maximal voluntary contractions (MVC). The results show an ~6% decrease in vastus lateralis thickness after the unloading period, which was fully restored after the subsequent training period in both the Ctrl and HIIT groups. MVC torque was decreased by ~11% after the unloading period and recovered fully during the subsequent training period in both groups. All-out cycling performance was improved by the 3 weeks of HIIT. In conclusion, the decline in muscle size and function after 3 weeks of unloading was restored by 3 weeks of resistance training regardless of whether it was combined with HIIT.
众所周知，缺乏运动可导致肌肉无力，并且有人提出，活性氧（ROS）水平的长期升高在这一过程中起核心致病作用。有趣的是，高强度间歇训练（HIIT）会产生大量ROS，但却能对ROS长期升高的病理状况产生积极影响。在此，让年轻男性志愿者的优势腿进行3周的去负荷，随后进行3周的阻力训练，其中一组不添加（对照组），另一组额外增加全力骑行HIIT。通过超声评估肌肉厚度变化，并通过测量最大自主收缩（MVC）时的扭矩来研究收缩功能。结果显示，去负荷期后股外侧肌厚度下降约6%，在随后的训练期，对照组和HIIT组的该指标均完全恢复。去负荷期后MVC扭矩下降约11%，两组在随后的训练期均完全恢复。3周的HIIT提高了全力骑行表现。总之，无论是否与HIIT相结合，3周的阻力训练均可恢复3周去负荷后肌肉大小和功能的下降。
