Soldani G, Bertelli A A, Mengozzi G, Polloni A, Bertelli A
Laboratory of Pharmacology, Veterinary School, University of Pisa, Italy.
Int J Tissue React. 1987;9(5):433-7.
The effects of three types of white wine (10% ethanol; pH 2.84-3.26), Coke (pH 2.45) and water (pH 8.03) on basal and food-stimulated gastric acid secretion in dogs were investigated. Water and Coke did not significantly modify acid secretion and gastrin release under basal conditions. By contrast, white wine or water +10% ethanol significantly increased acid secretion, with a tendency to elevate plasma gastrin concentrations. Acid secretion and gastrin release induced by a standard meal were not significantly modified by previous administration of Coke and water. In contrast, white wine and water +10% ethanol significantly increased food-stimulated total acid output, without changing plasma gastrin levels. It is concluded that Coke and water have only trivial effects on basal and on food-stimulated gastric acid secretion and gastrin release in the dog. The gastric stimulant effect of white wine is mainly related to its percentage of alcohol regardless of the slight differences in pH of the solutions.
研究了三种白葡萄酒（10%乙醇；pH 2.84 - 3.26）、可乐（pH 2.45）和水（pH 8.03）对犬基础胃酸分泌和食物刺激胃酸分泌的影响。在基础条件下，水和可乐对胃酸分泌和胃泌素释放无显著影响。相比之下，白葡萄酒或水 + 10%乙醇显著增加胃酸分泌，且有升高血浆胃泌素浓度的趋势。标准餐诱导的胃酸分泌和胃泌素释放不受先前给予可乐和水的显著影响。相反，白葡萄酒和水 + 10%乙醇显著增加食物刺激的总酸分泌量，而不改变血浆胃泌素水平。结论是，可乐和水对犬基础胃酸分泌、食物刺激胃酸分泌及胃泌素释放仅有轻微影响。白葡萄酒的胃刺激作用主要与其酒精含量有关，而与溶液pH值的微小差异无关。
