The effect of pirenzepine on gastric acid secretion and gastrin release induced by bombesin and meal in the dog.

Pirenzepine exerted a powerful inhibitory effect on gastric acid secretion from both the gastric fistula and the Heidenhain pouch of the dog, following intravenous infusion of bombesin. Similar results were obtained from the Heidenhain pouch when hypersecretion was stimulated by the meal test. The rise in plasma levels of radioimmunological gastrin, obtained by either bombesin or food administration, was not significantly affected by pirenzepine. The overall results indicate that the inhibitory effect of pirenzepine on gastric acid secretion in the dog was independent from the release of endogenous gastrin.