Del Tacca M, Soldani G, Polloni A, Bernardini C, Martinotti E
Scand J Gastroenterol Suppl. 1982;72:105-10.
Pirenzepine exerted a powerful inhibitory effect on gastric acid secretion from both the gastric fistula and the Heidenhain pouch of the dog, following intravenous infusion of bombesin. Similar results were obtained from the Heidenhain pouch when hypersecretion was stimulated by the meal test. The rise in plasma levels of radioimmunological gastrin, obtained by either bombesin or food administration, was not significantly affected by pirenzepine. The overall results indicate that the inhibitory effect of pirenzepine on gastric acid secretion in the dog was independent from the release of endogenous gastrin.
静脉注射蛙皮素后，哌仑西平对犬胃瘘和海登海因小胃的胃酸分泌均有强大的抑制作用。通过进餐试验刺激胃酸过度分泌时，海登海因小胃也得到了类似结果。无论是注射蛙皮素还是给予食物，引起的血浆放射免疫胃泌素水平升高均未受到哌仑西平的显著影响。总体结果表明，哌仑西平对犬胃酸分泌的抑制作用与内源性胃泌素的释放无关。
