Gotoh T, Koyanagi T, Tokunaka S
Hokkaido University School of Medicine, Sapporo, Japan.
Int Urol Nephrol. 1987;19(3):231-43. doi: 10.1007/BF02549860.
Renal morphology of various congenital ureteral anomalies was investigated to gain further insight into the genesis of associated renal dysplasia. Abnormality in the ureteral bud explains the genesis of renal dysplasia as long as the adjoining ureter is cranially ectopic. In caudal ectopy of either single or duplex system, no difference was found in the histologic quality of kidneys with G and H position orifice. In the single system kidneys of H position orifice, however, occurrence of renal dysplasia was not associated with obstruction, suggesting the operation of the "bud theory" even in single system caudal ectopy. In anomalies in which the ureteral orifice was not ectopic, it was suggested that renal parenchymal development was impaired by complete, but not by incomplete obstruction. The association of dysplastic ureter and renal dysplasia was not so frequent as anticipated and the hypodysplastic values of the kidneys with and without dysplastic ureters were similar, suggesting no direct causal relationship between them.
研究了各种先天性输尿管异常的肾脏形态，以进一步深入了解相关肾发育不全的发生机制。只要相邻输尿管为头侧异位，输尿管芽异常就可以解释肾发育不全的发生机制。在单系统或双系统尾侧异位中，具有G和H位置开口的肾脏组织学质量未发现差异。然而，在H位置开口的单系统肾脏中，肾发育不全的发生与梗阻无关，这表明即使在单系统尾侧异位中“芽理论”也起作用。在输尿管开口未异位的异常情况中，提示肾实质发育受到完全梗阻而非不完全梗阻的损害。发育异常的输尿管与肾发育不全的关联并不像预期的那样频繁，有和没有发育异常输尿管的肾脏发育不全值相似，表明它们之间没有直接因果关系。
