非编码 RNA 在海马神经发生中的调控作用及相关疾病的潜在治疗靶点。
Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related Disorders.
机构信息
Department of Anatomy, Institute of Neurobiology, Medical School, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China.
School of Pharmacy, Nantong University, Nantong 226001, China.
出版信息
Biomolecules. 2022 Dec 22;13(1):18. doi: 10.3390/biom13010018.
Non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, circRNAs, and piRNAs, do not encode proteins. Nonetheless, they have critical roles in a variety of cellular activities-such as development, neurogenesis, degeneration, and the response to injury to the nervous system-via protein translation, RNA splicing, gene activation, silencing, modifications, and editing; thus, they may serve as potential targets for disease treatment. The activity of adult neural stem cells (NSCs) in the subgranular zone of the hippocampal dentate gyrus critically influences hippocampal function, including learning, memory, and emotion. ncRNAs have been shown to be involved in the regulation of hippocampal neurogenesis, including proliferation, differentiation, and migration of NSCs and synapse formation. The interaction among ncRNAs is complex and diverse and has become a major topic within the life science. This review outlines advances in research on the roles of ncRNAs in modulating NSC bioactivity in the hippocampus and discusses their potential applications in the treatment of illnesses affecting the hippocampus.
非编码 RNA（ncRNAs），包括 microRNA、lncRNA、circRNA 和 piRNA，不编码蛋白质。然而，它们通过蛋白质翻译、RNA 剪接、基因激活、沉默、修饰和编辑等方式，在多种细胞活动中发挥着关键作用，如发育、神经发生、退化和神经系统损伤的反应；因此，它们可能成为疾病治疗的潜在靶点。海马齿状回颗粒下区的成年神经干细胞（NSCs）的活性对海马功能有重要影响，包括学习、记忆和情绪。ncRNAs 已被证明参与调节海马神经发生，包括 NSCs 的增殖、分化和迁移以及突触形成。ncRNAs 之间的相互作用复杂多样，已成为生命科学的一个主要课题。本文综述了 ncRNAs 在调节海马 NSCs 生物活性中的作用的研究进展，并讨论了它们在治疗影响海马的疾病中的潜在应用。
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