Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Department of Neurology, the Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.
Clin Interv Aging. 2022 May 9;17:745-753. doi: 10.2147/CIA.S363116. eCollection 2022.
We evaluated the diagnostic value of long non-coding RNA growth arrest-specific transcript 5 (GAS5) and its relationship with hippocampal volume in Alzheimer's disease (AD).
One hundred and eight patients with AD and 83 healthy controls were included, and demographic data, biochemical parameters, GAS5 levels, and hippocampal volume were recorded. Chi-squared tests or independent sample t-tests were used to compare the baseline characteristics, relative expression of GAS5, and hippocampal volume. Correlations between variables were determined using Spearman's rank correlation test. Receiver operating characteristic (ROC) curves were generated to compare the diagnostic value of GAS5 and total hippocampal volume in AD.
The levels of GAS5 were significantly upregulated in patients with AD compared with those in controls and were negatively correlated with MMSE score. There were differences in left hippocampal volume, right hippocampal volume, and total hippocampal volume between the two groups. Total hippocampal volume was positively correlated with MMSE score and negatively correlated with GAS5 expression in patients with AD. The area under the curve (AUC) of for GAS5 expression was 0.831, the sensitivity was 61.1%, and the specificity was 95.2%. The AUC of the combined total hippocampal volume was 0.891, the sensitivity was 74.1%, and the specificity was 92.8%.
The results suggested that GAS5 may be an excellent indicator of AD progression alone or in combination with hippocampal volume.
我们评估了长非编码 RNA 生长停滞特异性转录物 5（GAS5）及其与阿尔茨海默病（AD）中海马体积的关系的诊断价值。
纳入 108 例 AD 患者和 83 名健康对照者，记录人口统计学数据、生化参数、GAS5 水平和海马体积。采用卡方检验或独立样本 t 检验比较基线特征、GAS5 相对表达和海马体积。采用 Spearman 秩相关检验确定变量之间的相关性。绘制受试者工作特征（ROC）曲线比较 GAS5 和总海马体积在 AD 中的诊断价值。
AD 患者的 GAS5 水平明显高于对照组，且与 MMSE 评分呈负相关。两组间左侧海马体积、右侧海马体积和总海马体积存在差异。AD 患者的总海马体积与 MMSE 评分呈正相关，与 GAS5 表达呈负相关。GAS5 表达的曲线下面积（AUC）为 0.831，灵敏度为 61.1%，特异性为 95.2%。总海马体积的 AUC 为 0.891，灵敏度为 74.1%，特异性为 92.8%。
结果表明，GAS5 单独或与海马体积联合可能是 AD 进展的一个很好的指标。
