de Morais Viviane A Carvalho, de Oliveira-Pinto Ana V, Mello Neto Arthur F, Freitas Jaqueline S, da Silva Magnólia M, Suemoto Claudia Kimie, Leite Renata P, Grinberg Lea T, Jacob-Filho Wilson, Pasqualucci Carlos, Nitrini Ricardo, Caramelli Paulo, Lent Roberto
Neuroplasticity Laboratory, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
Biobank for Aging Studies, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246-903, SP, Brazil.
Brain Sci. 2023 Jan 5;13(1):104. doi: 10.3390/brainsci13010104.
Education is believed to contribute positively to brain structure and function, as well as to cognitive reserve. One of the brain regions most impacted by education is the medial temporal lobe (MTL), a region that houses the hippocampus, which has an important role in learning processes and in consolidation of memories, and is also known to undergo neurogenesis in adulthood. We aimed to investigate the influence of education on the absolute cell numbers of the MTL (comprised by the hippocampal formation, amygdala, and parahippocampal gyrus) of men without cognitive impairment.
The Isotropic Fractionator technique was used to allow the anisotropic brain tissue to be transformed into an isotropic suspension of nuclei, and therefore assess the absolute cell composition of the MTL. We dissected twenty-six brains from men aged 47 to 64 years, with either low or high education.
A significant difference between groups was observed in brain mass, but not in MTL mass. No significant difference was found between groups in the number of total cells, number of neurons, and number of non-neuronal cells. Regression analysis showed that the total number of cells, number of neurons, and number of non-neuronal cells in MTL were not affected by education.
The results indicate a resilience of the absolute cellular composition of the MTL of typical men to low schooling, suggesting that the cellularity of brain regions is not affected by formal education.
人们认为教育对大脑结构和功能以及认知储备有积极作用。受教育影响最大的脑区之一是内侧颞叶（MTL），该区域包含海马体，海马体在学习过程和记忆巩固中起重要作用，并且已知在成年期会发生神经发生。我们旨在研究教育对无认知障碍男性MTL（由海马结构、杏仁核和海马旁回组成）的绝对细胞数量的影响。
使用各向同性分割技术将各向异性的脑组织转化为核的各向同性悬浮液，从而评估MTL的绝对细胞组成。我们解剖了26例年龄在47至64岁之间、受教育程度低或高的男性的大脑。
两组在脑质量上存在显著差异，但在MTL质量上没有差异。两组在总细胞数、神经元数和非神经元细胞数方面未发现显著差异。回归分析表明，MTL中的总细胞数、神经元数和非神经元细胞数不受教育影响。
结果表明，典型男性MTL的绝对细胞组成对低教育程度具有弹性，这表明脑区的细胞数量不受正规教育的影响。
